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研究生: 楊煜民
Yu-Min Yang
論文名稱: 以注射式磁性複合材料結構導引磁性載具定位之研究
Magnetic shaping of ferrite-PDMS composite and its application in magnetic particle targeting
指導教授: 蘇育全
Yu-Chuan Su
口試委員:
學位類別: 碩士
Master
系所名稱: 原子科學院 - 工程與系統科學系
Department of Engineering and System Science
論文出版年: 2008
畢業學年度: 96
語文別: 中文
論文頁數: 82
中文關鍵詞: magnetic targeting
相關次數: 點閱:60下載:0
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  • 本研究主要是利用磁場與注射方式將磁性複合材料成型,利用此材料導引磁性粒子定位。將Mn - Zn鐵氧體粉末以固定體積濃度均勻分散在 PDMS 中形成磁性複合材料,在注射過程中利用控制磁場大小來影響表面能與磁能交互作用,產生均勻且細長的磁柱,控制磁場方向來導引此磁柱,形成包覆固定於管狀物上之環形結構,此結構可利用交流磁場加熱提高固化速度,並在適當磁場方向施加下,在此環形結構上下緣的局部區域,感應出較高磁場梯度,利用此磁場梯度可提高受磁化之磁性粒子在特定區域定位的效果,並在磁性粒子導引定位後,適時的移除或繼續施加外加磁場,可控制磁性粒子的釋放或再次聚集,此特性將有助於將具有包覆藥物的磁性粒子導引至欲治療的部位,提升藥物治療的效果。


    This work presents a structure forming scheme that is capable of remotely shaping magnetic composites into desired geometries. The magnetic composites, which are made up of fine ferrite particles in PDMS pre-polymer matrices, are injected into controlled magnetic fields and deformed by the induced magnetic and interfacial forces. Directed by the magnetic fields, the injected composites can be longitudinally extruded, wound around targeted structures and attached firmly to them. Once magnetically heated and solidified, the composite structures can potentially serve as implants to assist the targeting of magnetic particles. When energized by external magnetic fields, the implanted structures in turn produce short-ranged forces that can guide the targeting of nearby magnetic particles. As such, the desired internal attraction for magnetic carrier targeting can be achieved and switched on/off remotely, which localizes the retention of carriers, accelerates the release of drugs, and improves the therapeutic efficiency.

    目錄 摘要 I Abstract II 誌謝 III 目錄 IV 圖目錄 VII 第1章 緒論 1 1.1 前言 1 1.2 奈微脂體結構粒子 3 1.3 奈微磁球導引 4 1.4 研究動機與目標 5 1.5 論文架構 6 第2章 文獻回顧 7 2.1 磁性粒子藥物輸送 7 2.2 乳化均質研究 10 2.3 固態脂質粒子製程相關研究 12 2.4 磁性粒子與外加磁場特性 13 2.5 磁性粒子引導相關研究 16 第3章 工作原理 22 3.1 乳化均質機制 22 3.2 磁性物質與產熱機制 23 3.2.1 一般磁性物質性質 23 3.2.2 磁性粒子特性 25 3.2.3 磁性奈米粒子加熱機制 30 3.2.4 磁性流體與軟磁材料特性 34 3.3 磁場模擬 36 第4章 實驗方法 43 4.1 實驗材料 43 4.1.1 界面活性劑 43 4.1.2 固態脂質磁性粒子 45 4.2 磁性複合材料製作與成形 49 4.3 PMMA與PDMS裝置實驗 53 第5章 結果與討論 57 5.1 磁性複合材料實驗結果 57 5.1.1PDMS磁性複合材料界面特性 57 5.1.2 磁性複合材料交流磁場加熱硬化與磁性量測 68 5.2 流道裝置實驗結果 70 5.3 討論 75 第6章 結論與未來發展 77 6.1 結論 77 6.2 未來發展 78 參考文獻 79

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