粒線體是一個動態胞器，不停地進行融合與分裂，這個過程又稱為粒線體動態平衡。在細胞中，粒線體最主要的功能是藉由呼吸作用來提供能量；除此之外，還參與了許多的代謝與訊息傳遞的調控。先前研究指出，老化、疾病與粒線體功能異常有關，且粒線體會藉由融合與分裂來維持其正常的功能。在我們先前的研究中發現，老化的酵母菌其粒線體呈現較破碎的型態，並且會藉由提升粒線體功能來維持正常的細胞功能。而在酵母菌及線蟲的生物研究中發現，白藜蘆醇可提高粒線體的活性來延長壽命並且延緩老化的發生。我的實驗針對白藜蘆醇在老化的酵母菌中的作用進行研究。我們發現在老化的酵母菌細胞中加入白藜蘆醇可以減少衰老細胞族群中帶有破碎狀粒線體的比例，更進一步發現白藜蘆醇會改變衰老細胞中粒線體融合與分裂的基因表現、粒線體DNA的總量，以及提高氧氣的消耗量。我們的解果顯示白藜蘆醇在老化的細胞中會改變粒線體融合與分裂的平衡，並且進一步提升粒線體的功能。

Mitochondria are important organelles that play key roles in cellular functions, such as energy production, oxidative stress responses and programmed cell death. Proper mitochondria dynamics fission/fusion processes are critical for regulating their shape, size and integrity. The cellular activity declines gradually during the senescence process. Previous studies in our lab demonstrated that mitochondria not only become fragmented by shifting dynamic balance toward fission, but also alter their activity in replicative senescent yeast cells. Resveratrol is known to be an effective antioxidant and be able to extend lifespan by boosting mitochondria biogenesis and activity. However, the effects of resveratrol on mitochondria dynamics in replicative senescent yeast cells remain to be explored. We applied biotin-streptavidin labeling method to isolate resveratrol-treated senescent cells to clarify related issues. Our results demonstrated that treatment of resveratrol can reduce mitochondria fragmentation in replicative senescent yeast cells and increase fusion and fission gene expression levels. Furthermore, resveratrol increased mtDNA and enhanced the oxygen consumption. Our finding indicated that resveratrol possesses the ability to adjust the fusion and fission balance of mitochondria and further facilitates mitochondrial functions in senescent yeast cells.

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