根據行政院衛生署近十年研究報告顯示，在台灣地區腦血管疾病
一直高居國人十大死因之第二位，其中又以動脈瘤破裂致死占大多數，而人工支架為近年來治療動脈瘤的方法之一。在人工支架外形研究上，大多探討人工支架線徑與非商用人工支架形狀改變對瘤內流場之影響，且大多以直型母管為主，而針對商用人工支架去探討，大多為定性結果。在人工支架孔隙率(Cα)研究上，相關研究較少且大多以直型母管為主定性去觀察或是定量分析但卻是在穩態及實驗波形下。由上述可發現鮮少有文獻在脈動下以彎型母管搭配最危險之瘤體角度，定性與定量去探討人工支架形狀與孔隙率對於瘤內血液動力特性之影響。因此，本文旨在針對彎型母管之側向動脈瘤，在脈動下，以視流觀測法、質點影像測速儀及壓力量測，定性與定量探討人工支架形狀與孔隙率對於動脈瘤瘤內血液動力特性之影響，並與臨床實驗結果相互比較。在動脈瘤模型方面，瘤體與母管之夾角為45°，其選擇乃依據文獻報導，當瘤體角度為45°時，從血液動力特性觀點評估下較為危險(risky)，母管曲率為2.5，形狀之參數變化為固定孔隙率(Cα=80%)之自製單螺旋狀與商用螺旋狀兩種，孔隙率之參數變化為利用商用人工支架探討孔隙率(一、二、三層，Cα=80%、60%、40%)之影響。ICA波形脈動流場參數中沃門斯里數(Womersley Number)為4.0，雷諾數變化範圍為202~384。實驗結果乃透過血液動力參數如瞬時速度場、瘤內活動力、壁面剪應力與壓力等來呈現動脈瘤瘤內之血液動力特性。在人工支架孔隙率研究上，結果顯示血液動力因子量值會隨著孔隙率的減少而呈指數函數下降。歸納出孔隙率與壁面剪應力之關係並提供臨床治療上加裝二層人工支架後能加速血拴形成與加裝三層人工支架附加效用有限之依據，此外，也可供人工支架製造商在設計人工支架時之參考依據。最後將本實驗結果與體外相關研究、實際臨床結果相互比較佐證，本實驗結果可供未來相關數值模擬比較驗證。

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行政院衛生署：中華民國公共衛生概況。行政院衛生署，2007