傳統的輻射劑量學主要用來評估人體內器官或組織的吸收劑量，及其所引起的生物效應。但近來研究的目標從器官劑量（巨觀劑量學）到細胞劑量（微劑量學），進而到DNA劑量（奈米劑量學）。本研究將針對鄂惹發射體建構一個DNA奈米劑量模式，需要的基本資料有鄂惹電子能量，鄂惹電子與生物體產生不同作用的微分作用截面，以及生物物理學的幾何模型。並用FORTRAN程式語言，寫出一套蒙地卡羅模擬的程式，進而對DNA產生雙股斷裂或單股斷裂進行評估。找出對DNA的直接和間接作用最為有效的某一特定能量的鄂惹電子，評估此能量對DNA的傷害能力。也藉由改變放射性核種的種類和其與DNA雙股之間的幾何位置，試著評估出最有效的放射基因治療法。

參考文獻
1 T.M. Behr, et al., Therapeutic Advantages of Auger Electron over Beta Emitting Radiometals or Radioiodine when Conjugated to Internalizing Antibodies, European Journal of Nuclear Medicine, 27, 753-765, 2000.
2 AAPM Report No.37, Auger Electron Dosimetry, American Association of Physicists in Medicine, American Institute of Physics, 1993.
3 AAPM Report No.49, Dosimetry of Auger Electron Emitting Radionuclides, American Association of Physicists in Medicine, 1995.
4 Ton-Lian Chou and Chuan-Jong Tung, Interactions of Low Energy Electrons with Liquid Water, Natl. Sci. Counc. Monthly, ROC, 10(5), 411-420, 1982
5 C. J. Tung and C. P. Wang, Multiple Scattering of Low-Energy Electrons in Aluminum, IEEE Transactions on Nuclear Science, Vol. Ns-30, No. 6, December 1983
6 D.W.O. Rogers and A.F. Bielajew, Monte Carlo Techniques of Electron and Photon Transport for Radiation Dosimetry, National Research Council of Canada, Chapter 5, Vol. III of The Dosimetry of Ionizing Radiation, 1990
7 Alex F Bielajew, HOWFAR and HOWNEAR: Geometry Modeling for Monte Carlo Particle Transport, Draft Version: April 29, 1996
8 S. Ftacnikova and R. Bohm, Monte Carlo Calculations of Energy Deposition in DNA for Auger Emitters, Radiation Protection Dosimetry, Vol. 92, No. 4, pp. 269-278, 2000
9 Pinak, M. Theoretical Computational Simulation of DNA Damage by Ionizing Radiation. Doctoral dissertation, Department of Quantum Engineering and System Science, The University of Tokyo, 1994
10 Charlton, D. E. and Humm, J.L. A Method for Calculating Initial DNA Strand Breakage Following the Decay of Incorporated 125I. Int. J. Radiat. Biol. 53, 353-356, 1988
11 Michalik V., Maurizot Spotheim, M. and Charlier, M. Calculation of Hydroxyl Radical Attack on Different Forms of DNA. J. Biomol. Struct. Dyn. 13(3), 565-575, 1995
12 ICRU. Average Energy Required to Produce an Ion Pair, Report 31 (Washington, DC: ICRU Publications), 1979
13 Tomita, H., Kai, M., Kusama, T., Aoki, Y. and Ito, A. Monte Carlo Simulation of DNA Strand Breaks induced by Monoenergetic Electrons using Higher-order Structure Model of DNA. Int. J. Radiat. Biol. 66, 669-682, 1994
14 Rao, D. V., Narra, V. R., Howell, R. W. and Sastry, K. S. R. Biological Consequence of Nuclear versus Cytoplasmatic Decays of I-125. Cysteamine as a Radioprotector against Auger Cascades in vivo. Radiat. Res. 124, 188-193, 1990
15 Turner, J. E., Magee, J. L., Wright, H. A., Chatterjee, A., Hamm, R. N. and Ritchie, R. H. Physical and Chemical Development of Electron Tracks in Liquid Water. Radiat. Res. 96, 437-449, 1983
16 Humm, J. L. A new Calculational Method to Assess the Therapeutic Potential of Auger Electron Emission. Int. J. Radiat. Oncol. 17, 351-360, 1989
17 Pomplum, A. A new DNA Target Model for Track Structure Calculations and its First Application to 125I Auger Electrons. Int. J. Radiat. Biol. 59, 625-642, 1991