本研究以電噴灑式氣相奈米粒子電移動度分析儀 (electrospray-differential mobility analyzer，ES-DMA) 為基礎，開發孔性金屬有機框架 (metal-organic frameworks, MOF) 奈米材料穩定性的鑑定方法，藉由ES-DMA所測量得到的粒徑大小及數量濃度之變化，可分析膠體溶液中奈米粒子之間的聚集 (aggregation)、解聚 (de-aggregation) 與解體 (de-assembly) 現象。
　　首先第一部分實驗進行的是熱穩定性的分析，本研究在ES-DMA系統中加入溫程控制之能力 (temperature programmed, TP)， 組合成 TP-ES-DMA 系統，藉由調控管型高溫爐的溫度，觀察溫度變化對MOF粒徑的影響，進而對 MOF 膠體奈米材料之熱穩定性進行分析。首先，本研究測量UiO-66-NH2 以及UiO-66在經過加熱之後的粒徑變化，來觀察有機配位基的胺化對MOF熱穩定性的影響；另一方面則選擇MIL-88B-NH2 (Fe) 和 MIL-88B-NH2 (Cr) 來觀察MOF 之金屬節點對MOF熱穩定性的影響。結果顯示，有機配位基的胺化將使MOF的熱穩定性下降，而以鉻為金屬節點之MOF與鐵相較之下則有較好的熱穩定性。同時，本研究利用掃描式電子顯微鏡 (SEM) 測得之影像資訊來觀察 MOF 在溫度上升之後的外觀變化，也使用熱重分析法 (TGA) 及 X射線繞射分析 (XRD) 來測得 MOF 在高於熱分解溫度環境下的結構與組成變化，藉此驗證以TP-ES-DMA測量得到的結果。
　　第二部分實驗進行的是MOF作為藥物傳遞載體的應用，將消炎藥布洛芬 (Ibuprofen) 擔載於UiO-66-NH2之孔洞中製備成複合式奈米材料 (Ibu@ UiO-66-NH2)。首先利用表面積及孔徑分析儀 (BET) 和 TGA來對擔載於UiO-66-NH2的布洛芬進行定量分析，比較以不同載藥方式所得到的樣品之間的載藥量差異。接著利用ES-DMA測量樣品之電移動度粒徑，分析Ibu@ UiO-66-NH2材料在不同溶液中的化學穩定性，觀察其載藥前後的性質變化，同時也測量粒子之界面電位 (Zeta potential) 。結果顯示，若以濕式含浸法 (wet impregnation) 來擔載藥物，那麼藥物吸附在UiO-66-NH2 表面的情形較為明顯，而初濕含浸法 (incipient wetness impregnation) 相較之下有較多藥物擔載於UiO-66-NH2的孔洞之中。至於化學穩定性方面，載藥後的UiO-66-NH2在純水中的穩定性跟載藥前相比沒有太大的差異。在模擬人體體液環境之中，以兩種方式製備的 Ibu@ UiO-66-NH2 材料在酸性環境下的穩定性皆低於中性環境下的穩定性。
　　本研究證實了ES-DMA可用於鑑定MOF奈米材料的熱穩定性以及化學穩定性，除了能應用在觸媒以及生醫領域之外，未來還可以有更多元廣泛的應用。

We develop a facile aerosol-based method to study the stability of metal-organic framework (MOF) nanomaterial colloids based on electrospray-differential mobility analyzer (ES-DMA). Using the data of number concentration and particle size collected by ES-DMA, we further analyze behaviors of the nanoparticles in colloidal solution, such as aggregation, de-aggregation and de-assembly. We combine the temperature-programmed device with ES-DMA to establish the TP-ES-DMA system for evaluating the effect of the change in the temperature on the particle size of MOF. We also analyze the thermal stability of MOF colloids in response to the thermal treatment.
In the first part of the experiments, we chose UiO-66 and UiO-66-NH2 to determine the effect of aminization of organic ligand on thermal stability of MOF. In the second part, we chose MIL-88B-NH2(Fe) and MIL-88B-NH2(Cr) to observe the effect of metal complex node on their thermal stability. The results have shown that the aminization of organic ligand lowered the thermal stability, while the Cr-based MOF exhibited higher thermal stability than the Fe-based MOF did. In the meanwhile, we obtained images of MOF by SEM to observe the change in morphology after the rise in temperature. Also, we used TGA and XRD to measure the change in the structure and the composition of MOF at the temperature higher than the starting point of the thermal disintegration. The results from TGA and XRD can be used as the verification for those obtained by TP-ES-DMA.
In the second part of the experiments, we synthesized hybrid nanomaterials by encapsulating ibuprofen drugs in MOF for the application of drug delivery. We used BET analysis and TGA to determine the amount of drug loading for the comparison between different methods of drug encapsulation. We analyzed the chemical stability of Ibu@UiO-66-NH2 by measuring the mobility diameter and also the zeta potentials of particles. The results have shown that more drugs adsorbed on the surface of UiO-66-NH2 when synthesized by the wet impregnation method. In contrast, there would be more drugs presented in the pores by using the incipient wetness impregnation approach. The chemical stability of UiO-66-NH2 in water was not much affected by drugs encapsulation, however, in the simulated environment of human body fluid, the chemical stability of both type of Ibu@UiO-66-NH2 was much affected in acid condition than in neutral environment.
This study has proved that we can use ES-DMA to characterize the thermal stability and chemical stability of MOFs, not only can be used in applications of catalysis and biomedical area, but also can be used in other types of applications in the future.

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