近年來，使用中藥中毒的案例層出不窮，甚至有人將中藥副作用當成藥效的現象，中藥的成分和來源相當的複雜，因此會對內容物標示不詳盡，而不易讓人警覺其潛在的危險性。為了探討微量元素在中藥中對人體的關係。本研究以微量分析化學的方法，利用多元素石墨爐原子吸收光譜儀發展中藥（補中益氣湯）中微量元素的分析技術，達成同時及快速多元素分析之目標。
本研究使用多元素石墨爐原子吸收光譜儀，直接且同時測定中藥（補中益氣湯）中的銅、鎘和鉛元素，由於中藥粉中無機鹽類及不易溶於水的特性會對直接測量產生嚴重的干擾，因此先將中藥粉（補中益氣湯）微波消化，且三種元素在中藥樣品中的含量均低，故添加適當的鈀修飾劑，並尋找儀器最佳化設定。本分析方法為使用單純的去離子水（含0.2% HNO3）校正曲線，成功地定量標準尿液中的銅、鎘和鉛元素，測定值與ICP-MS偵測值並不會相差太大。

本方法應用中藥（補中益氣湯）的分析，回收率均在100±7%之內。此外，銅、鎘和鉛元素的偵測極限都很低，在灰化溫度600℃，原子化溫度1950℃，添加Pd修飾劑時，分別為0.74ppb，0.12ppb，0.03ppb；在灰化溫度為400℃及原子化溫度為2050℃，無添加鈀修飾時在原子化溫度為2150℃時，三元素之偵測極限分別為2.56ppb，0.59ppb及0.26ppb。相對標準偏差都小於8%。

A simple method was developed for the direct and simultaneous determination of copper, cadmium, and lead in urine by a multi-element graphite furnace atomic absorption spectrometer (Perkin-Elmer SIMAA 6000). Pd was used as the chemical modifier along with a purge gas (100% Ar). The matrix interferences were removed effectively so that a simple calibration curve method could be used (with microwave digestion). A Chinese medication sample (Bu-zhong-yi-qi-tang) used to find the optimal temperature program. The recovery (using the Bu-zhong-yi-qi-tang sample) were within 90%-110% for three elements. With the ashing temperature at 600℃, and the atomization temperature at 1950℃, the detection limits were 0.74 µg l-1 for Cu, 0.12 µg l-1 for Cd, and 0.03 µg l-1 for Pb. The relative standard deviations (RSDs) was lower than 8%.

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