表面聲波感測器結合奈米粒子在生化感測之應用

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研究生：	邱繼舜 Chiu,Chi-Shun
論文名稱：	表面聲波感測器結合奈米粒子在生化感測之應用 Biochemical Sensing Using Nanoparticle-based Surface Acoustic Wave Sensors
指導教授：	果尚志 Gwo,Shangjr
口試委員:
學位類別：	博士 Doctor
系所名稱：	工學院 - 奈米工程與微系統研究所 Institute of NanoEngineering and MicroSystems
論文出版年：	2008
畢業學年度：	97
語文別：	英文
論文頁數：	103
中文關鍵詞：	表面聲波感測器、奈米金粒子
相關次數：	點閱：2 下載：0
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奈米金粒子及DNA-奈米金粒子共軛物分別被固定基板表面形成奈米金粒子自組裝單層膜及功能性奈米金粒子自組裝單層膜。使用有機矽烷作為偶聯劑分別固定奈米金粒子及DNA-奈米金粒子共軛物在鈮酸鋰及二氧化矽鍍層的鉭酸鋰表面的方法已被開發在雷利及波導剪切水平表面聲波感測器的應用上。
在本研究中，藉由使用高解析度掃描式電子顯微鏡及表面聲波感測器對金奈米粒子的吸附動力學進行比較的量測，使得表面聲波感測器的頻率響應與吸附奈米金粒子的表面密度產生定量的關聯。藉由此方法，奈米金粒子被使用作為奈米砝碼在很大的線性動態範圍內量測質量負載的效應。雷利及波導剪切水平表面聲波感測器分別被使用於氣相與液相監測表面質量的變化。在氣相量測環境中工作頻率113.3 MHz的雷利表面聲波感測器的質量靈敏度(約20 Hz□cm2/ng)比傳統的石英晶體微天平高出100倍以上。此外，亦使用工作頻率121.3 MHz的波導剪切水平表面聲波感測器於奈米金粒子及DNA-奈米金粒子共軛物的吸附動力學的液相原位即時量測。其靈敏度的改善(約6 Hz□cm2/ng)及成功的偵測DNA-奈米金粒子共軛物為基於奈米粒子的表面聲波感測器在生物感測的應用上做準備。
藉由奈米金粒子固定探針生物分子作為表面聲波感測器的感測膜的方式為生物分析及醫學診斷上提供一個簡單且可再現的方法。實際的應用包括決定結合到直徑10奈米的奈米金粒子上的寡核苷酸數目及DNA偵測。在氣相環境中應用工作頻率135 MHz的氮化鋁薄膜表面聲波感測器在DNA的雜合偵測上，氮化鋁薄膜表面聲波感測器結合直徑10奈米及20奈米的奈米金粒子作為探針寡核苷酸的固定、DNA雜合的標記及訊號的放大。

Table of Contents
摘要    iii
Abstract    iv
Dedication    v
Acknowledgements    vi
Table of Contents    vii
List of Tables    xi
List of Figures    xii
Chapter 1: Introduction    1
    1.1    Biosensor    2
        1.1.1    Introduction    2
        1.1.2    Basic Concepts    3
        1.1.3    Common Types of Biosensors    3
        1.1.4    Summary    6
1.2    Surface Acoustic Wave Biosensors    7
        1.2.1    Introduction    7
        1.2.2    Shear Horizontal Surface Acoustic Wave Devices    8
        1.2.3    SAW Materials and Design    12
1.3    Nanosensor    12
1.4    Nanotechnology in SAW Biosensors    15
Chapter 2: Gold Nanoparticles and Their Bioconjugates    17
    2.1     Gold Nanoparticles    17
    2.2     DNA□Gold Nanoparticle Conjugates    19
    2.3     Experimental Section    21
        2.3.1    Materials    21
        2.3.2     Size Distribution and Average Mass of Gold Nanoparticles    21
        2.3.3     Preparation of Probe DNA Modified Gold Nanoparticles    23
    2.4 Verification for the Functionalization of Gold Nanoparticle by XPS    25
    2.5 Results and Discussion    27
Chapter 3: Surface Functionalization of Materials for Biochemical Sensing    31
    3.1     Introduction    31
    3.2     Aminosilane Functionalization on Piezoelectric Materials    32
    3.3     Experimental Section    34
        3.3.1     Materials    34
        3.3.2     X-ray photoelectron spectroscopy    35
    3.4     Results and Discussion    35
    3.5     Summary    38
Chapter 4: Characterization of Nanosystems Using Nanoparticle-Based Rayleigh-SAW Sensors    39
    4.1     Introduction    40
    4.2     Principle of SAW Sensors    43
    4.3     Experimental Section    46
        4.3.1     Materials and Functionalization of the Sensing Surfaces    46
        4.3.2     Adsorption of Gold Nanoparticles    46
        4.3.3     Rayleigh-SAW Device Configuration    46
    4.4     Results and Discussion    49
        4.4.1     Gold Nanoparticle Immobilization    49
        4.4.2     Rayleigh-SAW Gas Phase Measurement    52
        4.4.3     Comparison of Mass Sensitivities for Various Devices    55
    4.5    Applications    56
    4.6    Summary    57
Chapter 5: Nanoparticle-based Surface Acoustic Sensors for Biosensing in Liquids    58
    5.1     Introduction    58
    5.2     SAW Devices for Operation in Liquids    59
        5.2.1     SH-mode SAW Sensors    60
        5.2.2     Guided SH-SAW Sensors    62
    5.3     Fabrication of guided SH-SAW Sensors    63
        5.3.1     Transducer Metallization    64
        5.3.2     Acoustic Waveguides for Guided SH-SAW Sensors    64
        5.3.3     Guided SH-SAW Sensors Based on Lithium Tantalate    65
    5.4     Experimental Section    67
        5.4.1     Materials    67
        5.4.2     Functionalization of the Sensing Surfaces    68
        5.4.3     Guided SH-SAW Device Configuration    68
        5.4.4     Preparation of Probe DNA Modified Gold Nanoparticles    70
        5.4.5     Estimation of Thiolated Oligonucleotides Loaded on Gold Nanoparticles    70
    5.5     Results and Discussion    71
Chapter 6: Aluminum Nitride-Based Surface Acoustic Wave Sensors and Biochemical Applications    76
    6.1     Introduction    76
    6.2     Propagation of Surface Acoustic Waves in Aluminum Nitride Films    78
    6.3     Experimental Section    79
        6.3.1     Material Growth    79
        6.3.2     Fabrication of AlN-Based SAW Devices    81
        6.3.3     Characterization of AlN-Based SAW Sensors    83
    6.4     Results and Discussion    85
    6.5     Future Development of AlN-Based SAW Devices    89
Chapter 7: Conclusions    90
Chapter 8: Perspectives    91
References    92
VITA    103

                                

References
Chapter 1
(1) Turner, A. P. F.; Karube, I.; Wilson, G. S. Biosensors: Fundamentals and Applications, Oxford, Oxford University Press: 1987.
(2) Mohanty, S. P.; Kougianos, E. Potentials, IEEE 2006, 25, 35–40.
(3) Campbell, C. K. Surface acoustic wave devices for mobile and wireless communications; Academic Press Inc.: San Diego, CA, 1998.
(4) Ballantine, D. S.; White, R. M.; Martin, S. J.; Ricco, A. J.; Zellers, E. T.; Frye, G. C.; Wohltjen, H. Acoustic Wave Sensors: Theory, Design and Physico-Chemical Applications ; Academic Press Inc.: San Diego, CA, 1997.
(5) Wohltjen, H.; Dessy, R. Anal. Chem. 1979, 51, 1458–1464.
(6) Dorozhkin, L. M.; Rozanov, I. A. J. Anal. Chem. 2001, 56, 399–416.
(7) Calabrese, G. S.; Wohltjen, H.; Roy, M. K. Anal. Chem. 1987, 59, 833–837.
(8) Janshoff, A.; Galla, H. J.; Steinem, C. Angew. Chem. 2000, 39, 4004–4032
(9) Wohltjen, H. Sens. Actuators 1984, 5, 307–325.
(10) Galipeau, D. W.; Story, P. R.; Vetelino, K. A.; Mileham, R. D. Smart Mater Struct. 1997, 6, 658–667.
(11) Drobe, H.; Leidl, A.; Rost, M.; Ruge, I. Sens Actuators A. 1993, 37–38, 141–148.
(12) Flory, C. A.; Baer, R. L. Proc. 1987 Ultrason. Symp. 1987, 313–318.
(13) Moriizumi, T.; Unno, Y.; Shiokawa, S. Proc. 1987 Ultrason. Symp. 1987, 579–582.
(14) Baer, R. L.; Flory, C. A.; Tom-Moy, M.; Spira-Solomon, D. Proc. 1992 Ultrason. Symp. 1992, 293–298.
(15) Inoue, Y.; Kato, Y.; Sato, K. J. Chem. Soc. Faraday Trans. 1992, 88, 449–454.
(16) Kondoh, J.; Matsui, Y.; Shiokawa, S. Jpn. J. Appl. Phys. 1993, 32, 2376–2379.
(17) Gizeli, E; Goddard, N. J.; Lowe, C. R.; Stevenson, A. C. Sens Actuators B 1992, 6, 131–137.
(18) Gizeli, E.; Stevenson, A. C.; Goddard, N. J.; Lowe, C. R. IEEE Trans Ultrason Ferroelectr. Freq. Control. 1992, 39, 657–659.
(19) Stevenson, A. C.; Gizeli, E.; Goddard, N. J.; Lowe, C. R. Sens Actuators B 1993, 13–14, 635–637.
(20) Kovacs, G.; Venema, A. Appl Phys Lett 1992, 61, 639–641.
(21) Kovacs, G.; Lubking, G. W.; Vellekoop, M. J.; Venema, A. Proc IEEE Ultrason Symp 1992, 281–285.
(22) Kovacs, G.; Vellekoop, M. J.; Haueis, R.; Lubking, G. W.; Venema, A. Sens Actuators A 1994, 43, 38–43.
(23) Du, J.; Harding, G. L.; Ogilvy, J. A.; Dencher, P. R.; Lake, M. Sens Actuators A 1996, 56, 211–219.
(24) Harding, G. L.; Du, J.; Dencher, P. R.; Barnett, D.; Howe, E. Sens Actuators A 1997, 61, 279–286.
(25) Collings, A. F.; Caruso, F. Rep Prog Phys 1997, 60, 1397–1445.
(26) Länge, K.; Rapp, B. E.; Rapp, M. Anal. Bioanal. Chem.2008, 391, 1509–1519.
(27) Hur, Y.; Han, J.; Seon, J.; Pak, Y. E.; Roh, Y. Sens Actuators A 2005, 120, 462–467.
(28) Sakong, J.; Roh, H.; Roh, Y. Jpn. J. Appl. Phys. 2007, 46, 4729–4733.
(29) Gronewold, T. M. A.; Baumgartner, A.; Quandt, E.; Famulok, M. Anal. Chem. 2006,78, 4865–4871.
(30) Shimizu, Y. Jpn. J. Appl. Phys. 1993, 32, 2183–2187.
(31) Bogue, R. W. Sensor Review, 2004, 24, 253–260.
(32) Khanna, V. K. Sensor Review, 2008, 28, 39–45.
(33) Staufer, U.; Akiyama, T.; Gullo, M. R.; Han, A.; Imer, R.; de Rooij, N. F.; Aebi, U.; Engel, A.; Frederix, P. L. T. M.; Stolz, M.; Friederich, N. F.; Wirz, D. Microelectronic Engineering, 2007, 84, 1681–1684.
(34) Xian, Y.; Hu, Y.; Liu, F.; Xian, Y.; Wang, H.; Jin, L. Biosensors &Bioelectronics 2006, 21, 1996-2000.
(35) Carrascosa, L. G.; Moreno, M.; Salvages, M.; Lechuga, L. M. TrAC Trends in Analytical Chemistry, 2006, 25, 196-206.
(36) Gould, P. Materials Today, 2007, 10, 10.

Chapter 2
(1) Daniel, M. C.; Astruc, D. Chem. Rev. 2004, 104, 293–346.
(2) Niemeyer, C. M. Angew. Chem., Int. Ed. 2001, 40, 4128–4158.
(3) Schmid, G.; Ed. Clusters and Colloids, VCH, Weinheim, 1994.
(4) Schroedter, A.; Weller, H. Angew. Chem., Int. Ed. 2002, 41, 3218–3221.
(5) Alivisatos, A. P. Science 1996, 271, 933–937.
(6) Feldheim, D. L.; Keating, C. D. Chem. Soc. Rev. 1998, 27, 1–12.
(7) Shipway, A. N.; Katz, E.; Willner, I. ChemPhysChem. 2000, 1, 18–52.
(8) F. Remacle, R. D. Levine, ChemPhysChem 2001, 2, 21–36.
(9) Turkevitch, J.; Stevenson, P. C.; Hillier, J. Discuss. Faraday Soc. 1951, 11, 55–75.
(10) Frens, G. Nature: Phys. Sci. 1973, 241, 20–22.
(11) Watson, K. J.; Zhu, J.; Nguyen, S. B. T.; Mirkin, C. A. J. Am. Chem. Soc. 1999, 121, 462–463.
(12) H. Dugas, Bioorganic Chemistry, Springer, New York, 1989.
(13) Diederichsen, U.; Lindhorst, T. K.; Westermann, B.; Wessjohann, L. A. Bioorganic Chemistry, Wiley-VCH, Weinheim, 1999.
(14) (a) Yang, X.; Wenzler, L. A.; Qi, J.; Li, X.; Seeman, N. C. J. Am. Chem. Soc. 1998, 120, 9779–9786; (b) Winfree, E.; Liu, F.; Wenzler, L. A.; Seeman, N. C. Nature 1998, 394, 539–544.
(15) Mirkin, C. A.; Letsinger, R. L.; Mucic, R. C.; Storhoff, J. J. Nature 1996, 382, 607–609.
(16) Patolsky, F.; Ranjit, K. T.; Lichtenstein, A.; Willner, I. Chem. Commun. 2000, 1025–1026.
(17) Letsinger, R. L.; Elghanian, R.; Viswanadham, G.; Mirkin, C. A. Bioconjugate Chem. 2000, 11, 289–291.
(18) Demer, L. M.; Mirkin, C. A.; Mucic, R. C.; Reynolds, R. A. III; Letsinger, R. L.; Elghanian, R.; Viswanadham, G. Anal. Chem. 2000, 72, 5535–5541.
(19) Johnson, S. R.; Evans, S. D.; Mahon, S. W.; Ulman, A. Langmuir 1997, 13, 51–57.
(20) Kumar, A.; Pattarkine, M.; Bhadbhade, M.; Mandale, A. B.; Ganesh, K. N.; Datar, S. S.; Dharmadhikari, C. V.; Sastry, M. Adv. Mater. 2001, 13, 341–344.
(21) Heister, K.; Zharnikov, M.; Grunze, M.; Johansson, L. S. O.; Ulman, A. Langmuir 2001, 17, 8–11.
(22) Heister, K.; Frey, S.; Gölzhäuser, A.; Ulman, A.; Zharnikov, M. J. Phys. Chem. B 1999, 103, 11098–11104.
(23) Tshida, T.; Hara, M.; Kojima, I.; Tsuneda, S.; Nishida, N.; Sasabe, H.; Knoll, W. Langmuir 1998, 14, 2092–2096.
(24) Castner, D. G.; Hinds, K.; Grainger, D. W. Langmuir 1996, 12, 5083–5086.
(25) Laiho, T.; Leiro, J. A.; Lukkari, J. Appl. Surf. Sci. 2003, 212, 525–529
(26) Zhong, C. J.; Brush, R. C.; Anderegg, J.; Porter, M. D. Langmuir 1999, 15, 518–525.
(27) Shlyakhtenko, L. S.; Gall, A.; Weimer, J.; Hawn, D. D.; Lyubchenko, Y. L. Biophys. J. 1999, 77, 568–576.
(28) Sastry, M.; Ramakrishnan, V.; Pattarkine, M.; Ganesh, K. N. J. Phys. Chem. B 2001, 105, 4409–4414.

Chapter 3
(1) Ulman, A. Chem. Rev. 1996, 96, 1533–1554.
(2) Taton, K. S.; Guire, P. E. Colloids Surf. B 2002, 24, 123–132.
(3) Hu, M.; Noda, S.; Okubo, T.; Yamaguchi, Y.; Komiyama, H. Appl. Surf. Sci. 2001, 181, 307–316.
(4) Prime, K. L.; Whitesides, G. M. Science 1991, 252, 1164–1167.
(5) Prime, K. L.; Whitesides, G. M. J. Am. Chem. Soc. 1993, 115, 10714–10721.
(6) Ferretti, S.; Paynter, S.; Russel, D. A.; Sapsford, K. E.; Richardson, D. J.; Trends Anal. Chem. 2000, 19, 530–540.
(7) Aswal, D. K.; Lenfant, S.; Guerin, D.; Yakhmi, J. V.; Vuillaume, D. Anal. Chim. Acta 2006, 568, 84–108.
(8) Brzoska, J. B.; Azouz, I. B.; Rondelez, F. Langmuir 1994, 10, 4367–4373.
(9) Wasserman, S. R.; Tao, Y.-T.; Whitesides, G. M. Langmuir 1989, 5, 1074–1087.
(10) Kojio, K.; Ge, S.; Takahara, A.; Kajiyama, T. Langmuir 1998, 14, 971–974.
(11) Doudevski, I.; Hayes, W. A.; Schwartz, D. K. Phys. Rev. Lett. 1998, 81, 4927–4930.
(12) Schwartz, D. K.; Steinberg, S.; Israelachvili, J.; Zasadzinski, J. A. N. Phys. Rev. Lett. 1992, 69, 3354–3359.
(13) Wang, A.; Tang, H.; Cao, T.; Salley, S. O.; Ng, K. Y. J. Colloid Interf. Sci. 2005, 291, 438–447.
(14) Denoyel, R.; Glez, J. C.; Trens, P. Colloid Surf. A 2002, 197, 213–223.
(15) Horr, T. J.; Arora, P. S. Colloid Surf. A 1997, 126, 113–121.
(16) Krasnoslobodtsev, A. V.; Smirnov, S. N. Langmuir 2002, 18, 3181–3184.
(17) Allen, G. C.; Sorbello, F.; Altavilla, C.; Castorina, A.; Ciliberto, E. Thin Solid Films 2005, 483, 306–311.
(18) Petri, D. F.; Wenz, G.; Schunk, P.; Schimmel, T. Langmuir 1999, 15, 4520–4523.

Chapter 4
(1) Shipway, A. N.; Katz, E.; Willner, I. ChemPhysChem. 2000, 1, 18–52.
(2) Daniel, M. C.; Astruc, D. Chem. Rev. 2004, 104, 293–346.
(3) Penn, S. G.; He, L.; Natan, M. J. Curr. Opin. Chem. Biol. 2003, 7, 609–615.
(4) Katz, E.; Willner, I. Angew. Chem. Int. Ed. 2004, 43, 6042–6108.
(5) Fritzsche, W.; Taton, T. A. Nanotechnology 2003, 14, R63–R73.
(6) Foultier, B.; Moreno-Hagelsieb, L.; Flandre, D.; Remacle, J. IEE Proc.-Nanobiotechnol. 2005, 152, 3–12.
(7) Zhou, X. C.; O’Shea, S. J.; Li, S. F. Y. Chem. Commun. 2000, 953–954.
(8) (a) Patolsky, F.; Ranjit, K. T.; Lichtenstein, A.; Willner, I. Chem. Commun. 2000, 1025–1026. (b) Weizmann, Y.; Patolsky, F.; Willner, I. Analyst 2001, 126, 1502–1504. (c) Willner, I.; Patolsky, F.; Weizmann, Y.; Willner, B. Talanta 2002, 56, 847–856.
(9) (a) Lin, L.; Zhao, H. Q.; Li, J. R.; Tang, J. A. ; Duan, M. X. ; Jiang, L. Biochem. Biophys. Res. Commun. 2000, 274, 817–820. (b) Zhao, H. Q.; Lin, L.; Li, J. R.; Tang, J. A.; Duan, M. X.; Jiang, L. J. Nanopart. Res. 2001, 3, 321–323. (c) Liu, T.; Tang, J.; Zhao, H.; Deng, Y.; Jiang, L. Langmuir 2002, 18, 5624–5626. (d) Liu, T.; Tang, J.; Jiang, L. Biochem. Biophys. Res. Commun. 2004, 313, 3–7.
(10) Ebara, Y.; Itakura, K.; Okahata, Y. Langmuir 1996, 12, 5165–5170.
(11) Branch, D. W.; Brozik, S. M. Biosens. Bioelectron. 2004, 19, 849–859.
(12) Ballantine, D. S.; White, R. M.; Martin, S. J.; Ricco, A. J.; Zellers, E. T.; Frye, G. C.; Wohltjen, H. Acoustic Wave Sensors: Theory, Design and Physico-Chemical Applications ; Academic Press Inc.: San Diego, CA, 1997.
(13) Campbell, C. K. Surface acoustic wave devices for mobile and wireless communications; Academic Press Inc.: San Diego, CA, 1998.
(14) Wohltjen, H.; Dessy, R. Anal. Chem. 1979, 51, 1458–1464.
(15) Wohltjen, H. Sens. Actuators 1984, 5, 307–325.
(16) Cunningham, A. Introduction to Bioanalytical Sensors; John Wiley & Sons: 1998.
(17) (a) Freeman, R. G.; Grabar, K. C.; Allison, K. J.; Bright, R. M.; Davis, J. A.; Guthrie, A. P.; Hommer, M. B.; Jackson, M. A.; Smith, P. C.; Walter, D. G.; Natan, M. J. Science 1995, 267, 1629–1632. (b) Grabar, K. C.; Freeman, R. G.; Hommer, M. B.; Natan, M. J. Anal. Chem. 1995, 67, 735–743. (c) A. Doron, A.; Katz, E.; Willner, I. Langmuir, 1995, 11, 1313–1317. (d) Lahav, M.; Gabai, R.; Shipway, A. N.; Willner, I. Chem. Commun., 1999, 1937–1938.
(18) Grabar, K. C.; Allison, K. J.; Baker, B. E.; Bright, R. M.; Brown, K. R.; Freeman, R. G.; Fox, A. P.; Keating, C. D.; Musick, M. D.; Natan, M. J. Langmuir 1996, 12, 2353–2361.
(19) Schmitt, J.; Mächtle, P.; Eck, D.; Möhwald, H.; Helm, C. A. Langmuir 1999, 15, 3256–3266.
(20) Chen, C. F.; Tzeng, S. D.; Lin, M. H.; Gwo, S. Langmuir 2006, 22, 7819–7824, and references therein.
(21) Martin, S. J.; Frye, G. C.; Senturia, S. D. Anal. Chem. 1994, 66, 2201–2219
(22) Grabar, K. C.; Smith, P. C.; Musick, M. D.; Davis, J. A.; Walter, D. G.; Jackson, M. A.; Guthrie, A. P.; Natan, M. J. J. Am. Chem. Soc. 1996, 118, 1148–1153.
(23) Caruso, F.; Furlong, D. N.; Niikura, K.; Okahata, Y. Colloids and Surface B : Biointerface 1998, 10, 199–204.
(24) Bizet, K.; Gabrielli, C.; Perrot, H. Analusis 1999, 27, 609–616.
(25) Lazcka, O.; Campob, F. J. D.; Muñoz, F. X. Biosens. Bioelectron. 2007, 22, 1205–1217
(26) Josse, F.; Dahint, R.; Schumacher, J.; Grunze, M.; Andle, J. C.; Vetelino, J. F. Sens Actuators A 1996, 53, 243–248.
(27) Francis, L.; Friedt,J. -M.; De Palma, R.; Zhou, C.; Bartic, C.; Campitelli, A.; Bertrand, P. IEEE International Ultrasonics Conference 2004, 241–249.
(28) Du, J.; Harding, G. L.; Ogilvy, J. A.; Dencher, P. R.; Lake, M. Sens Actuators A 1996, 56, 211–219.
(29) Martin, S. J.; Ricco, A. J.; Niemczyk, T. M.; Frye, G. C. Sens Actuators A 1989, 20, 253–258.
(30) Harding, G. L. Sens Actuators A 2001, 88, 20–28.

Chapter 5
(1) Shipway, A. N.; Katz, E.; Willner, I. ChemPhysChem. 2000, 1, 18–52.
(2) Daniel, M. C.; Astruc, D. Chem. Rev. 2004, 104, 293–346.
(3) Penn, S. G.; He, L.; Natan, M. J. Curr. Opin. Chem. Biol. 2003, 7, 609–615.
(4) Katz, E.; Willner, I. Angew. Chem. Int. Ed. 2004, 43, 6042–6108.
(5) Zhou, X. C.; O’Shea, S. J.; Li, S. F. Y. Chem. Commun. 2000, 953–954.
(6) (a) Patolsky, F.; Ranjit, K. T.; Lichtenstein, A.; Willner, I. Chem. Commun. 2000, 1025–1026. (b) Weizmann, Y.; Patolsky, F.; Willner, I. Analyst 2001, 126, 1502–1504. (c) Willner, I.; Patolsky, F.; Weizmann, Y.; Willner, B. Talanta 2002, 56, 847–856.
(7) (a) Lin, L.; Zhao, H. Q.; Li, J. R.; Tang, J. A. ; Duan, M. X. ; Jiang, L. Biochem. Biophys. Res. Commun. 2000, 274, 817–820. (b) Zhao, H. Q.; Lin, L.; Li, J. R.; Tang, J. A.; Duan, M. X.; Jiang, L. J. Nanopart. Res. 2001, 3, 321–323. (c) Liu, T.; Tang, J.; Zhao, H.; Deng, Y.; Jiang, L. Langmuir 2002, 18, 5624–5626. (d) Liu, T.; Tang, J.; Jiang, L. Biochem. Biophys. Res. Commun. 2004, 313, 3–7.
(8) Ballantine, D. S.; White, R. M.; Martin, S. J.; Ricco, A. J.; Zellers, E. T.; Frye, G. C.; Wohltjen, H. Acoustic Wave Sensors: Theory, Design and Physico-Chemical Applications ; Academic Press Inc.: San Diego, CA, 1997.
(9) Lewis, M. Proceedings of IEEE Ultrasonics Symposium, 1977, 744–752.
(10) Auld, B. A. Acoustic Fields in Solids; Malabar: R. E. Krieger 2nd edn., Vol. I, 1990
(11) Campbell, C. K. Surface acoustic wave devices for mobile and wireless communications; Academic Press Inc.: San Diego, CA, 1998.
(12) Curtin, S.; Jakoby, B.; Berthold, A.; Varadan, V. K.; Varadan, V. V., Vellekoop, M. J. Proceedings of Smart Electronics and MEMS (SPIE), San Diego, CA, 1998, 194–200.
(13) Thompson, D. F.; Auld, B. A. Proceedings of the IEEE Ultrasonics Symposium, 1986, 261–266.
(14) Baer, R. L.; Flory, C. A.; Tom-Moy, M.; Solomon, D. S. Proceedings of the IEEE Ultrasonics Symposium, 1992, 293–298.
(15) Jakoby, B.; Vellekoop, M. J. Smart Mater. Struct. 1997, 6, 668–679.
(16) Johnson, G.; Foise, J. Encycl. Appl. Phys. 1996, 15, 365–375.
(17) Nakamura, K.; Kazumi, M.; Shimizu, H. Proceedings of the IEEE Ultrasonics Symposium 1977, 819–822.
(18) Sze, S.M. (ed.) VLSI Technology, 2nd edn., Singapore: McGraw-Hill, 1988.
(19) Kovacs, G.; Vellekoop, M. J.; Haueis, R.; Lubking, G.W.; Venema, A. Sens. Actuators A 1994, 43, 38–43.
(20) Herrmann, F.; Weihnacht, M.; Büttgenbach, S. Ultrasonics 1999, 37, 335–341.
(21) Jakoby, B.; Vellekoop, M. J. IEEE Trans. Ultrasonics Ferroelec. Freq. Control 2000, 47, 696–700.
(22) Mirkin, C. A.; Letsinger, R. L.; Mucic, R. C.; Storhoff, J. J. Nature 1996, 382, 607–609.
(23) Demer, L. M.; Mirkin, C. A.; Mucic, R. C.; Reynolds, R. A. III; Letsinger, R. L.; Elghanian, R.; Viswanadham, G. Anal. Chem. 2000, 72, 5535–5541.

Chapter 6
(1) Stutzmann, M.; Garrido, J. A.; Eickhoff, M.; Brandt, M. S. Phys. Stat. Sol. A 2006, 203, 3424–3437.
(2) Chaniotakis N.; Sofikiti, N. Anal. Chim. Acta 2008, 615, 1–9.
(3) Bgoldr, B.; Steinhoff, G.; Hernando, J.; Purrucker, O.; Tanaka, M.; Nickel, B.; Stutzmann, M.; Eickhoff, M. Appl. Phys. Lett. 2005, 87, 263901.
(4) Chen, C. -F.; Wu, C. -L.; Gwo, S. Appl. Phys. Lett. 2006, 89, 252109.
(5) Petoral, J. R. M.; Jr.; Yazdi, G. R.; Spetz, A. L.; Yakimova, R.; Uvdal, K. Appl. Phys. Lett. 2007, 90, 223904.
(6) Steinhoff, G.; Purrucker, O.; Tanaka, M.; Stutzmann, M.; Eickhoff, M. Adv. Funct. Mater. 2003, 13, 841–846.
(7) Kang, B. S.; Ren, F.; Wang, L.; Lofton, C.; Tan, W. W.; Pearton, S. J.; Dabiran, A.; Osinsky, A.; Chow, P. P. Appl. Phys. Lett. 2005, 87, 023508.
(8) Kang, B. S.; Pearton, S. J.; Chen, J. J.; Ren, F.; Johnson, J. W.; Therrien, R. J.; Rajagopal, P. J.; Roberts, C.; Piner, E. L.; Linthicum, K. J. Appl. Phys. Lett. 2006, 89, 122102.
(9) Bgoldr, B.; Howgate, J.; von Ribbeck, H. -G.; Gawlina, Y.; Bandalo, V.; Steinhoff, G.; Stutzmann, M.; Eickhoff, M. Appl. Phys. Lett. 2006, 89, 183901.
(10) Chiu, C. S.; Gwo, S. Anal. Chem. 2008, 80, 3318–3326.
(11) Takagi, Y.; Santos, P. V.; Wiebicke, E.; Brandt, O.; Schönherr, H. -P.; Ploog, K. H. Appl. Phys. Lett. 2002, 81, 2538–2540.
(12) Caliendo, C.; Imperatori, P. Appl. Phys. Lett. 2003, 83, 1641–1643.
(13) Xu, J.; Thakur, J. S.; Zhong, F.; Ying, H.; Goldner, G. W. J. Appl. Phys. 2004, 96, 212.
(14) Campbell, C. K. Surface acoustic wave devices for mobile and wireless communications; Academic Press Inc.: San Diego, CA, 1998.
(15) Ballantine, D. S.; White, R. M.; Martin, S. J.; Ricco, A. J.; Zellers, E. T.; Frye, G. C.; Wohltjen, H. Acoustic Wave Sensors: Theory, Design and Physico-Chemical Applications ; Academic Press Inc.: San Diego, CA, 1997.
(16) Drafts, B. IEEE Trans. Microwave Theory and Techniques 2001, 49, 795–802.
(17) Schmidt, F.; Scholl, G. Int. J. High Speed Electron. Syst. 2000, 10, 1143–1191.
(18) Bulst, W. -E.; Fischergolder, G.; Reindl, L. IEEE Trans. Industrial Electronics 2001, 48, 265–271.
(19) Caliendo, C.; Imperatori, P.; Cianci, E. Thin Solid Films 2003, 441, 32–37.
(20) Ambacher, O. J. Phys. D: Appl. Phys. 1998, 31, 2653–2710.
(21) Palacios, T.; Calle, F.; Monroy, E.; Muñoz, E. J. Vac. Sci. Technol. B 2002, 20, 2071–2074.
(22) Wu, C. -L.; Wang, J. -C.; Chan, M. -H.; Chen, T. T.; Gwo, S. Appl. Phys. Lett. 2003, 83, 4530–4532.
(23) Clement, M.; Vergara, L.; Sangrador, J.; Iborra, E.; Sanz-Hervás, A. Ultrasonics 2004, 42, 403–407.
(24) Ingrosso, I.; Petroni, S.; Altamura, D.; De Vittorio, M.; Combi, C.; Passaseo, A. Microelectron. Eng. 2007, 84, 1320–1324.
(25) Rimeika, R.; Ciplys, D.; Shur, M. S.; Gaska, R.; Khan, M. A.; Yang, J. phys. stat. sol. (B) 2002, 234, 897–900.
(26) Mirkin, C. A.; Letsinger, R. L.; Mucic, R. C.; Storhoff, J. J. Nature 1996, 382, 607–609.
(27) Deger, C.; Born, E.; Angerer, H.; Ambacher, O.; Stutzmann, M.; Hornsteiner, J.; Riha, E.; Fischerauer, G. Appl. Phys. Lett. 1998, 72, 2400–2402.
(28) Pedrósa, J.; Calle, F.; Grajal, J.; Jiménez Riobóo, R.J.; Prieto, C.; Pau, J. L.; Pereiro, J.; Hermann, M.; Eickhoff, M.; Bougrioua, Z. Superlattices and Microstructures 2004, 36, 815–823.

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