本篇論文目的為製備可在6’-, 2-進行修飾之醣脂神經醯胺核心化合物(18) (6’-, 2-aminos galactosyl phytosphingosine)。論文中6’-, 2-胺基醣脂神經醯胺核心化合物之製備，醣端予體(6)是由商品化半乳醣經6步合成而得，產率為25%。受體(13)則由商品化神經鞘胺醇經由4步合成而得，產率為56%。再經由醣基化反應可得到醣脂質類似物，產率97%，而α/β比值為3。
核心化合(18) (6’-, 2-aminos galactosyl phytosphingosine)經由去甲醯基與氫化而得，總產率11.7%。
核心化合最後經由醯胺化最終分別得到醣脂神經醯胺類似物(19)、(20)、(21)、(22)。經由HPLC純化後，將分析其對於iNKT-Cell誘導增生之能力。

This thesis is aimed to prepare 6’-, 2-derivatized galactosylceramide analogs. Before preparation of core compound (18) 6’-, 2-aminos galactosyl phytosphingosine, donor (6) and acceptor (13) were firstly prepared. The sugar moiety (6) was obtained via a 6-step synthesis, starting from commercial galactose in 25% yield; the acceptor (13) was prepared from commercial phytosphingosine via 4-step synthesis in 41% yield. Then via glycosylation we obtained glycolsphingosine analog in 97% yield with α/β ratio of 3/1.
The core compound (18) was obtained via debenzoylation and hydrolysis and the total yield was 11.7%.
The final 6’-, 2-derivatized galactosylceramide analogs (19), (20), (21), (22), was obtained via amide bond formation and purified through HPLC. The analogs will be analyzed its potential as iNKT-Cell inducer.

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