本論文主要是鈷、鎳、銠金屬錯合物應用在催化環化反應上的研究。第一章我們發表一種方便方法合成具有高位置位向選擇性茚胺、茚酮亞胺與茚酮衍生物，此反應以鄰鹵素苯醛、胺類與炔類當起始物，在鋅粉為還原劑鈷金屬催化條件下進行，此反應產物為茚胺衍生物與先前利用鎳、鈀金屬催化產物異喹啉衍生物不同，此外在鈷金屬與鎳金屬催化下此兩產物具有不同位置化學選擇性，並且可以被解釋。茚胺衍生物並且可以用來合成具有高生物活性的茚酮衍生物。
在第二章的研究中，我們則是延續上一章實驗成果，在[CoI2(dppf)]/ZnCl2催化系統下，methyl 2-(2-(trimethylsilyl)ethynyl)benzoate 與o-halo-benzaldimines 進行多鍵生成反應，此反應產物為茚并異喹啉酮衍生物，此反應具有高位置化學選擇性與高產率優點。進一步在SeO2的氧化下，合成indenoisoquinolin-dione衍生物。同時順利合成具藥物活性茚并異喹啉酮衍生物2.28u與2.19，並有效提升合成效率。
在第三章的部份，我們利用鈷金屬催化系統，發展出o-(methoxycarbonyl)phenylboronic acid 與丙炔醇或丙炔醯胺衍生物，藉由配位基改變得到兩種環化反應途徑。兩種環化反應途徑選擇性主要由兩種雙芽配位基Dppe與Dppm控制，順利合成出異色滿酮、異喹啉酮與茚酮衍生物。
第四章中，我們利用簡單與方便的鎳金屬催化系統，成功的將2-鹵素苯醯胺與炔類進行環化反應，得到高產率異喹啉酮衍生物。此方法亦可應用起始物丙烯酯，順利得到1-異吲哚啉酮衍生物。同時順利應用在天然物oxyavicin的合成上。
最後一個章節，利用銠金屬催化系統，將苯醯胺與炔類衍生物進行環化反應，得到異喹啉酮衍生物，反應機制藉由碳-氫鍵活化與碳-氮鍵生成。此方法亦可應用在合成1-異吲哚啉酮衍生物。

In this thesis, we have demonstrated a series of cobalt, nickel and rhodium-catalyzed annulations and their application in organic synthesis are discussed in detail. The thesis is divided into five chapters. The first chapter explains the synthesis of indenamines, indene–enamines and indenones derivatives, the second chapter describes the preparation of indenoisoquinolinones derivatives, the third chapter describes the synthesis of indenones derivatives, the fourth and fifth chapter describes the synthesis of isoquinolone and isoindolinone derivatives.
Chapter 1 : We have demonstrated a new three component methodology for the synthesis of substituted indenamines, indenimines and indenones via a cobalt-catalyzed three component reaction. The reaction is highly regioselective and various functionalized indenamine derivatives can be prepared. The interesting difference of products, regiochemistry and mechanisms from those of the previous nickel-catalyzed o-halobenzaldimines and alkynes that gave isoquinoline products is arisen from the different natural properties of 5-membered azametalcycles of cobalt and nickel.

Chapter 2 : In the presence of [CoI2(dppf)] and ZnCl2, the methyl 2-(2-(trimethylsilyl)ethynyl)benzoate and its congeners undergo multiple bond forming reactions with o-halo-benzaldimines. To produce diverse kinds of indenoisoquinolinone derivatives in good to excellent yields. Further oxidation of these derivative using SeO2 results indenoisoquinolin-dione derivatives in excellent yields. Finally, as an application of these methods biologically active indenoisoquinolinone derivatives 2.28u and 2.19 were prepared in a very short fashion.

Chapter 3 : We have demonstrated cobalt catalyzed two types of annulation reactions of o-(methoxycarbonyl)phenylboronic acid with propargyl alcohol or amide derivatives via the ligand tuning. The additional bidentate phosphine ligands gave regioselective formation of isochromanone, isoquinolinone and indenone derivatives in good to excellent yield.

Chapter 4: We have demonstrated a easy and convenient nickel-catalyzed annulation reaction of substituted 2-halobenzamides with alkynes to give the corresponding isoquinolinone in good yields. The nickel-catalyzed annulation reactions of acrylate also proceeded smoothly to give isoindolinone derivatives in good yields. The present protocol is successfully applied to the total synthesis of oxyavicine with excellent yield.

Chapter 5: We have successfully developed a new efficient rhodium catalyzed synthesis of substituted isoquinoline derivatives from the reaction of aromatic amides and alkynes. The transformation involves an rhodium-catalyzed C-H bond activations and C-C/C-N bond formations in one-pot. The present protocol is also successfully applied to synthesis of isoindolinone derivatives.

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