血液動力因子普遍被認為與顱內動脈瘤之形成與破裂有關，然而部分重要的血液動力特性卻難以經由活體量測獲得，且一般體外實驗又因模型過度簡化，導致所得結果無法真實重現動脈瘤內血流情形。因此本文旨在以影像重建技術、數值模擬及視流觀測探討顱內內頸動脈(ICA)瘤之血液動力特性，並說明其與動脈瘤發展和破裂機制之關聯性。研究中利用一序列之MRA斷層影像結合三維重建技術建構出實體動脈瘤結構，並以非結構化網格之有限體積離散方法模擬計算於實驗波形下之瘤內脈動流場，且搭配與重建相近似之體外90°動脈瘤模型視流觀測實驗輔助驗證相關的流場特性，而後為求更逼近真實人體血流情形，進一步以人體ICA波形進行運算。數值方法旨在求解依時性不可壓縮Navier-Stokes方程組，其中時間精度為二階Crank-Nicolson法，空間精度於對流項與擴散項分別採用二階上風法與中央差分法，並搭配SIMPLEC演算法解決壓力與速度耦合問題。計算上，實驗波形與ICA波形脈動流場參數中沃門斯里數(Womersley Number)分別為3.9與4.0，雷諾數變化範圍為300~850與201.8~383.5。計算結果乃透過探討血液動力參數諸如瘤內速度向量場、渦漩結構、流入瘤體流量、瘤壁剪應力與壓力分佈等來呈現瘤內血流動力特性。結果顯示於兩種脈動波形下動脈瘤瘤頂處均存在著局部之剪應力與壓力突升現象，且搭配臨床研究結果更推斷出瘤頂位置之劇烈壓力變化為造成動脈瘤破裂的重要因素。

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