本次實驗利用微機電技術及製程，製作微流體元件，並以該元件配合流體的操控，改變不同的流體特性以及系統進行操控測試，利用了流體的不穩定性，成功的產生了直徑大小微米到奈米尺寸的液珠，達成微米(micron)以下的monodispersion，製作出尺寸更小的液珠。希望在生醫的應用上可以提供更好的效果，未來也將朝應用於liposome之產生方面以及使元件操控以及液珠分離的方式更加成熟。

[01]Takasi Nisisako, Toru Torii and Toshiro Higuchi “Droplet formation in a
microchannel network” Lab Chip, 2002, 2, 24–26
[02] Shingo Okushima, Takasi Nisisako, Toru Torii, and Toshiro
Higuchi“Controlled Production of Monodisperse Double Emulsions by
Two-Step Droplet Breakup in Microfluidic Devices” Langmuir 2004, 20,
9905-9908
[03] Takasi Nisisako, Shingo Okushima and Toru Torii “Controlled formulation
of monodisperse double emulsions in a multiple-phase microfluidic system”
Soft Matter, 2005, 1, 23–27
[04] Piotr Garstecki, Michael J. Fuerstman,a Howard A. Stonec and George M.
Whitesides“Formation of droplets and bubbles in a microfluidic
T-junction—scaling
And mechanism of break-up” Lab Chip, 2006, 6, 437–446
[05] Shelley L. Anna, Nathalie Bontoux and Howard A. Stone“Formation of
dispersions using ‘‘flow focusing’’ in microchannels” Appl. Phys. Lett.,
January 2003 Vol. 82, No. 3, 20 364-366
[06] Thomas Ward,Magalie Faivre,,Manouk Abkarian,Howard A.
Stone“Microfluidic flow focusing: Drop size and scaling in pressure versus
flow-rate-driven pumping” Electrophoresis 2005, 26, 3716–3724
66
[07] Zhihong Nie, Shengqing Xu, Minseok Seo, Patrick C. Lewis, and Eugenia
Kumacheva“Polymer Particles with Various Shapes and Morphologies
Produced in Continuous Microfluidic Reactors ” J. AM. CHEM. SOC. 2005,
127, 8058-8063
[08] Minseok Seo, Zhihong Nie, Shengqing Xu, Michelle Mok, Patrick C.
Lewis, Robert Graham, and Eugenia Kumacheva“Continuous Microfluidic
Reactors for Polymer Particles” Langmuir 2005, 21, 11614-11622
[09] Sinoj Abraham, Eun Ho Jeong, Takahiro Arakawa, Shuichi Shoji, Kyung
Chun Kim, Il Kim and Jeung Sang Go“Microfluidics assisted synthesis of
well-defined spherical polymeric microcapsules and their utilization as
potential encapsulants” Lab Chip, 2006, 6, 752–756
[10] Shinji Sugiura, Mitsutoshi Nakajima, Satoshi Iwamoto,and Minoru
Sek“Interfacial Tension Driven Monodispersed Droplet Formation from
Microfabricated Channel Array ” Langmuir 2001, 17, 5562-5566
[11] Suz-Kai Hsiung, Cheng-Tso Chen and Gwo-Bin Lee“Micro-droplet
formation utilizing microfluidic flow focusing and controllable moving-wall
chopping techniques”
J. Micromech. Microeng. 16 (2006) 2403–2410
[12]A. S. Utada, E. Lorenceau, D. R. Link, P. D. Kaplan, H. A. Stone, D. A.
Weitz “Monodisperse Double Emulsions Generated from a Microcapillary
Device”Science2005 vol 308 537-541
67
[13] Takeuchi S, Garstecki P, Weibel DB, Whitesides GM “An axisymmetric
flow-focusing microfluidic device” Advanced Materials 2005 17 (8):
1067-1072 APR 18
[14] Shih-Hao Huang,Wei-Heong Tan, Fan-Gang Tseng, and Shoji Takeuchi “A
monolithically three-dimensional flow-focusing device for formation of
single/double emulsions in closed/open microfluidic systems ” J. Micromech.
Microeng. 16 (2006) 2336–2344
[15] Link DR, Grasland-Mongrain E, Duri A, Sarrazin F, Cheng ZD, Cristobal
G, Marquez M, Weitz DA “Electric Control of Droplets in Microfluidic
Devices” Angew. Chem. Int. Ed. 2006, 45, 2556 –2560
[16] Ahn K, Kerbage C, Hunt TP, Westervelt RM, Link DR, Weitz
DA“Dielectrophoretic manipulation of drops for high-speed microfluidic
sorting devices” Appl. Phys. Lett. 88, 024104 _2006_
[17] Yung-Chieh Tan and Abraham Phillip Lee“Microfluidic separation of
satellite droplets as the basis of a monodispersed micron and submicron
emulsification system” Lab Chip, 2005, 5, 1178–1183
[18] Zhihong Nie, Wei Li, Minseok Seo, Shengqing Xu, and Eugenia
Kumacheva“Janus and Ternary Particles Generated by Microfluidic Synthesis:
Design, Synthesis, and Self-Assembly” J. AM. Chem. SOC. 2006, 128,
9408-9412
68
[19] Loscertales IG, Barrero A, Guerrero I, Cortijo R, Marquez M,
Ganan-Calvo AM i “Micro/nano encapsutation via electrified coaxial liquid
jets” Science 295 (5560): 1695-1698 MAR 1 2002
[20] http://upload.wikimedia.org/wikipedia/en/d/d6/HD-Rayleigh-Taylor.gif
[21]http://upload.wikimedia.org/wikipedia/commons/e/e3/Wavecloudsduval.jp
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