硼中子捕獲治療(boron neutron capture therapy, 簡稱BNCT)發展至今近70年，為現今國際上正積極發展的腫瘤治療技術之一。許多國家如美國、日本、荷蘭及義大利等皆將其核反應器應用於BNCT上，近年來更已達臨床治療階段。國內清華大學開放式水池反應器(Tsing Hua open-pool reactor, 簡稱THOR)亦致力於BNCT之研究，期望未來能造福更多病患。在THOR應用於臨床治療病患前，首要工作為利用實驗度量及模擬計算等方式來評估射束品質及假體劑量。
本論文採用組織等效比例計數器(Tissue Equivalent Proportional Counter, 簡稱TEPC)作為度量工具，模擬細胞大小，利用雙計數器微劑量技術(dual counter microdosimetric technique)量測在空氣中及假體不同深度處之THOR混合輻射場能譜，藉以觀測能量沉積變化情形及各輻射所造成之吸收劑量貢獻。此外，經生物加權因數(biological weighting function, r(y))轉換計算可得到深度-有效相對生物效應(effective relative biological effectiveness, effective RBE)曲線、中子相對生物效應(neutron RBE)、光子相對生物效應(photon RBE)與硼中子捕獲相對生物效應(BNC RBE)，不但可作為THOR之射束品質評估依據，更可與國際間各中子設施之輻射品質相互比較；未來，治療計畫所得之物理劑量總和(total physical dose)或各輻射之物理劑量(physical dose)，利用本論文之effective RBE或neutron RBE、photon RBE與BNC RBE轉換，可進一步得到RBE劑量，作為治療效果評估參考。

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