雖然一般觀念中把眼鏡蛇歸類於神經性毒性，但是台灣眼鏡蛇咬傷主要產生局部紅腫及肢體壞死，且壞死組織容易造成革蘭氏陰性細菌的感染，而神經毒性的表現：神經—肌肉傳導阻斷及呼吸困難的症狀，約佔5%而已。有研究指出，局部組織的壞死並非因為細菌感染傷口造成，而是來自於蛇毒中的心臟毒素。我們發現在東、西部的台灣眼鏡蛇毒液中，不僅其毒力強弱明顯不同，且心臟毒素的表現也有不同的模式，我們懷疑這可能在傷口造成程度不等的傷害，所以針對東、西部台灣眼鏡蛇毒液中的不同的毒蛋白做了毒性的比較。因為心臟毒素的作用機制，是屬於細胞膜毒素的一種，而且有證據顯示心臟毒素會造成骨骼肌細胞的壞死，故在實驗中我們以蛇毒對細胞及肌肉組織的毒性表現來做觀察。結果顯示，蛇毒中的毒蛋白彼此之間明顯存在著協同的作用，且東、西部的眼鏡蛇毒確實有不同的生理毒性差異。根據細胞及動物實驗的觀察推測，相同劑量的蛇毒，西部(白腹1型)眼鏡蛇的細胞與肌肉毒性最高；東部(黑腹)眼鏡蛇與另一型的西部(白腹2型)眼鏡蛇則互有不同。而這個差異顯然是來自於心臟毒素的不同表現，在進一步比較不同的毒蛋白後，發現西部(白腹1型)眼鏡蛇含量最多的心臟毒素A3有最強的細胞與肌肉毒性；西部(白腹2型)眼鏡蛇含量較高的心臟毒素A2、A4有較強的細胞毒性，而東部(黑腹)眼鏡蛇含量較高的心臟毒素A1、A6則有較強的肌肉毒性。若再考慮蛇咬的單次排毒量，則東部(黑腹)眼鏡蛇的肌肉毒性應超過西部(白腹)眼鏡蛇4倍以上。

Though we sort out the cobra in nerve toxicity in the general idea , some red and swollen in local tissue and limbs necrosis are downright bad that emerges from Taiwan cobra(Naja atra) bite mainly, and the necrosis tissue is apt to infect with the Gram's negative bacterium , and the nerve toxicity: blocking neuron— muscle conducts and difficulty in breathing , just account for 5% . Study points out that the necrosis does not cause by bacterial infection , but by cardiotoxin of snake venom. We find that in the east and western Taiwan cobra venom , not merely its poisonous strength power is obviously different , and the composition of the cardiotoxin has different ways, we suspect that this may cause the wound injury in different degrees , so we has directed against the different toxin proteins in the east and western Taiwan cobra venom and make toxicity comparison. Because of the functional mechanism of the cardiotoxin is one kind of the membrane toxin , and the evidence shows that the cardiotoxin will cause the necrosis of the skeletal muscle cell , so we observe the cell toxicity and myotoxicity of the snake venom in the experiment . The result shows that the toxin proteins in the snake venom obviously have synergistic effect , and the east and western cobra venom really have different toxicity in physiology . Infer according to observation of the cell and animal experiment , by the same dosage of snake venom , the west(white belly 1) cobra have the highest cell toxicity and myotoxicity ; the cobra of east(black belly) and another type of west(white belly 2) have difference each other . And the differences are come from cardiotoxin obviously . To compare with different toxin proteins , we find that in the west( white belly 1) cobra , the most contents— cardiotoxin A3 has the strongest cell and muscle toxicity ; and in the west(white belly 2) cobra , the higher contents—cardiotoxin A2 , A4 have stronger cell toxicity ; and higher contents of the east(black belly) cobra , cardiotoxin A1 , A6 have stronger myotoxicity . If we consider the venom quantity by every single time which the snake bites , then the myotoxicity of the east(black belly) cobra should exceed more than 4 times of cobra in the west (white belly).

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覃公平 主編
中國毒蛇學(CHINA POISONOUS SNAKE RESEARCH)
廣西科學技術出版社出版 1999年 第三版