由於氧化鐵奈米粒子具有尺寸優勢和磁性，故漸漸為許多研究團隊所重視。氧化鐵奈米粒子所具有的小尺寸優勢，使其可利用於人體內的研究；而其所具有的磁性，使得氧化鐵奈米粒子，再配合適當的儀器（如：磁振造影儀，MRI），可做為有效的偵測工具。目前研究均偏向於將氧化鐵奈米粒子鍵結於具有生物相容性的偵測物質上，並藉著特有的lock-key特性，使得偵測物質可以和特定物質做結合，再加上外加磁場，我們即可利用鍵結於偵測物質上之氧化鐵奈米粒子的磁性得知其位置。
由於氧化鐵奈米粒子具有嚴重的聚集現象，故本研究首要的目的就是希望能夠有效的分離奈米粒子，降低聚集現象。在本研究中，尺寸6~8nm的氧化鐵奈米粒子可經由合成得到，再利用葵酸和十二酸修飾在奈米粒子表面形成單層保護膜及雙層保護膜。之後利用紅外線光譜儀及熱重量分析儀得到單層膜及雙層膜修飾於粒子表面之證據。另外還將具有chromism特性的PDA（polydiacetylene）分子修飾於氧化鐵奈米粒子外，不僅可做為防止聚集現象的保護膜，也可以藉由PDA分子因鍵結其他物質產生變色的性質來確認是否鍵結。並且同樣利用紅外線光譜儀集中熱重分析儀進行修飾膜的確認，並且利用紫外光光譜儀證明PDA分子chromism的現象。

Because of the superparamagnetic property of iron oxide nanoparticles, more and more research groups were interested in the magnetic nanoparticles whether in fundamental or technological applications. And also the advantage of small size, iron oxide nanoparticles can be applied in human bodies. Nanoparticles were combined to bio-compatible compounds in recent researches, and by the lock-key character, magnetic nanoparticles can coordinate with specific materials. Then, when putting an external magnetic field, magnetic particles can be considered as a tracer.
The Severe aggregation of iron oxide nanoparticles has always been a problem for practical uses, so the purpose of this thesis is to reduce the aggregation phenomenon of particles by surface modification. Particles with an average size of 6~8nm can be obtained by wet chemical method, and monolayer and bilayer made of lauric acid and decanoic acid were both modified on the surface of particles as a protective layer. IR microscope and thermal gravimetric analysis (TGA) were used to identify the existence of monolayer and bilayer. Besides, PDA molecules with chromism character were also modified outer particles. They were not only a protective layer, but also a sensor that can examine the bonding between PDA molecules and specific molecules through the change of the color of PDA. In the same way, IR and TGA were used to identify the surface modification, and UV microscope was also used to present the chromism character of PDA molecules.

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