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| 研究生： |
陳彥辰 Chen, Yen-Chen |
|---|---|
| 論文名稱： |
鈣離子通道在泊松-能斯特-普朗克-費米模型之數值模擬 Numerical Simulations of Calcium Channel by Poisson–Nernst–Planck–Fermi Model |
| 指導教授： |
劉晉良
Liu, Jinn-Liang |
| 口試委員: |
陳仁純
Chen, Ren-Chuen 陳人豪 Chen, Jen-Hao |
| 學位類別： |
碩士 Master |
| 系所名稱： |
南大校區系所調整院務中心 - 應用數學系所 應用數學系所(English) |
| 論文出版年： | 2017 |
| 畢業學年度： | 106 |
| 語文別： | 英文 |
| 論文頁數： | 24 |
| 中文關鍵詞： | 鈣離子通道 、泊松-能斯特-普朗克-費米模型 |
| 外文關鍵詞： | Calcium Channel, Poisson–Nernst–Planck–Fermi Model |
| 相關次數： | 點閱：3 下載：0 |
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鈣離子通道是在許多生物機能上扮演重要的角色。本研究使用CaVAb channel 的資料。雖然我們只研究選擇性的那個區域但仍然模擬整個離子通道。首先用兩種不同的軟體來觀察，並比較兩軟體。然後用PNPF 理論模型來分析此離子結合的構造，並得到相關的數值模擬結果。
Calcium channels play an important role in many biological functions. This thesis considers the CaVAb channel constructed via the homotetrameric bacterial NaV channel NaVAb by Tang et al. in 2014 [9]. Although we only focus on the selectivity part of the channel, numerical simulations have been performed in the entire channel with intra- and extracellular baths. We start by using two different softwares to observe channel and compare the two softwares. Then we use the PNPF Model to analyze the structure of the ion binding and produce numerical results.
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[5] Liu, J.-l. Author ’ s personal copy Numerical methods for the Poisson–Fermi equation in electrolytes. 88–99.
[6] Liu, J. L., and Eisenberg, B. Correlated ions in a calcium channel model: A Poisson-Fermi Theory. Journal of Physical Chemistry B 117, 40 (2013), 12051–12058.
[7] Liu, J. L., and Eisenberg, B. Poisson-Nernst-Planck-Fermi theory for modeling biological ion channels. The Journal of Chemical Physics 141, 22 (2014), 22D532.
[8] Liu, J. L., and Eisenberg, B. Numerical methods for a Poisson-Nernst-Planck-Fermi model of biological ion channels. Physical Review E 92, 1 (2015), 12711.
[9] Tang, L., El-din, T. M. G., Payandeh, J., Martinez, G. Q., Heard, T. M., Scheuer, T., Zheng, N., and Catterall, W. A. Structural basis for Ca 2 1 selectivity of a voltage-gated calcium channel. Nature 505, 7481 (2014), 56–61.