本實驗室已成功的發展出一有效率合成「四氫化1,4苯二氮平酮」之方法。為了推廣其應用性與探討取代基對反應之影響，我們使用不同取代基之鹵素芳香環作為起始物。

An efficient method has been developed previously for the synthesis of tetrahydrogenated 1,4-benzodiazepin-5-ones. To extend the reaction application and to study the substituent effect, we used various substituted aryl halides as the starting materials. Substituents on aryl halides including the electron-withdrawing groups such as thio, amino, and trifluoromethyl groups, or the electron-donating group, such as methyl, isopropyl, and phenyl groups have been studied. The desired substituted benzodiazepinones were obtaind in 20–70% yields. We also performed the same reactions with the parent arenes without any substituent and obtained benzodiazepinone in low yield.

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