綠原酸（CGA，Chlorogenic acid）是一種廣泛存在於自然界各植物中的一種分子，擁有多種異構物，最常見的為5-咖啡醯奎尼酸（5-O-caffeoylquinic acid），俗名仍同樣通稱為『綠原酸』。除了本身即是一種抗氧化物，目前也有許多文獻指出綠原酸尚具有控制體重、預防癌症、糖尿病或心血管疾病等能力。
　　在本研究中，我們的研究是著重在綠原酸是否具有美白潛力，並以老鼠黑色素瘤細胞（B16F0）做為測試平台，發現在不影響細胞生長型態的前提下，讓細胞與含有綠原酸濃度0.6 mM的培養液接觸兩到三天之後，細胞內黑色素含量與酪胺酸□活性會減少為控制組的72%和61%，與此同時，酪胺酸□的基因表現和蛋白質數量也會減少，而所有的抑制效果皆與細胞接觸的綠原酸濃度成正比。此外，我們亦使用雙倒數作圖法（Lineweaver-Burk）觀察綠原酸在酵素反應中的抑制行為，確認其為非競爭型抑制劑。自我們的研究結果中，我們發現綠原酸能夠透過抑制酪胺酸□基因表現，減少酪細胞內的胺酸□蛋白質數量，進而減低最後的黑色素生成量。而我們的研究成果也證明綠原酸具有擔任美白藥物的潛力。

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