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研究生： 林泓瑞
Lin, Hung-Ruei
論文名稱： 生物可分解共聚高分子PGSA-VAc之研究
Synthesis and Characterization of Biodegradable PGSA-VAc co-Polymer
指導教授： 王潔
Wang, Jane
口試委員: 陳信龍
Chen, Hsin-Lung
劉大佼
Liu, Ta-Jo
學位類別： 碩士
Master
系所名稱： 工學院 - 化學工程學系
Department of Chemical Engineering
論文出版年： 2018
畢業學年度： 106
語文別： 英文
論文頁數： 61
中文關鍵詞： 生物可降解 、聚酯類高分子 、光聚合 、醫療設備 、丙烯酸化聚甘油癸二酸酯 、醋酸乙烯酯
外文關鍵詞： biodegradable, polyester, photocurable, medical device, poly(glycerol sebacate) acrylate (PGSA), vinyl acetate (VAc)
相關次數： 點閱：3  下載：0 
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    • 過去十年，具有黏彈性的生物可降解材料的開發逐漸受到關注與歡迎，黏彈體特殊的性質被應用開發在各種領域，故黏彈體的需求也隨之大幅度上升。

    基於聚（甘油癸二酸脂），加入可光固化官能基，合成出聚甘油癸二酸酯丙烯酸酯（PGSA），並添加乙酸乙烯酯（VAc）與PGSA混合共聚以增加機械性能，同時保持生物降解性。通過紫外光固化，機械性能可以更穩定，最重要的是透過積層製造聚合物的形狀可以被精密的控制，進而製造出對應形狀或造型的醫療器材。

    隨著人口的持續增長，對於可以被生物降解的醫療器械還有可以用於臨床植入式的聚合物的需求一直在增加。透過光固化交聯聚合的積層製造科技提供了快速和可定制的選擇，並且得以製造具有生物相容性，生物降解性的一次性設備。

    The development of biodegradable materials with elastomeric properties had become one of the most popular research topics in the past decade, and the need to produce new elastomeric polymers in large scale for a wide variety of applications had been ever increasing.

    Based on the synthesis of poly (glycerol sebacate)-based photocurable biodegradable polymer, poly (glycerol sebacate) acrylate (PGSA), vinyl acetate (VAc) is added to increase the mechanical properties while maintaining the biodegradability. With UV-curing, the mechanical property can be more stable and most importantly is that the shape of polymer can be controlled by additive manufacturing.

    The demand for biodegradable medical devices and implantable polymers for clinical use had been increasing along with the continuous growth of population. Biodegradable photocurable polymeric material coupling with additive manufacturing provides a fast and customizable option to make biocompatible, biodegradable and disposable devices.

    Abstract I 摘要 I 致謝 II Table of Content 1 Chapter 1 Introduction 6 1.1 Introduction to Biomaterial 6 1.1.1 Introduction to Biocompatibility 8 1.1.2 Introduction to Cells used in the Determination of Biocompatibility 9 1.1.2 Common Medical Devices 11 1.1.3 Global Use of Polymeric Materials in Medical Devices 15 1.2 Introduction to Biodegradable Polymer 16 1.2.1 Background of Biodegradable Polymer 16 1.2.2 Introduction to Biodegradation 16 1.2.3 Mechanisms of Biodegradation 16 1.2.4 Introduction to Common Biodegradable Polymers 20 1.3 Motivation and Objective 23 1.4 Introduction to Poly (Glycerol Sebecate) and Poly (Glycerol Sebacate) Acrylate 24 1.4.1 Poly (Glycerol Sebecate) (PGS) 24 1.4.2 Poly (Glycerol Sebacate) Acrylate (PGSA) 26 1.5 Introduction to Poly (Vinyl Alcohol) and Poly (Vinyl Acetate) 27 1.5.1 Co-Polymers and Blends Derived from PVA 28 1.6 Polymer Crosslinking and Film Formation 29 1.6.1 Physical Crosslinking in Polymers 29 1.6.2 Chemical Crosslinking in Polymers 29 1.7 Introduction to Additive Manufacturing 31 1.8 Introduction to Venous Thromboembolism 32 1.8.1 Risk Factors of Venous Thromboembolism 33 1.8.2 Prevention and Treatment of Venous Thromboembolism 33 Chapter 2 Experimental Methods 35 2.1 Materials and Equipment 35 2.2 Synthesis Process 37 2.2.1 Synthesis of PGS Pre-Polymer 37 2.2.2 Synthesis of PGSA Pre-Polymer and PGSA-VAc co-Polymer 37 2.3 Characterization of PGSA-VAc co-Polymer 38 2.3.1 Rheology and Viscosity Tests 38 2.3.2 Mechanical Tests 38 2.3.3 Thermal Tests 38 2.3.4 Glass Transition Temperature Measurements 39 2.3.5 Degradation Tests 39 2.3.6 Swelling Tests 39 2.3.7 Contact Angle Tests 39 2.3.8 Biocompatibility and Cytotoxicity Tests 40 2.3.9 3D-Printing System 40 Chapter 3 Results and Discussions 41 3.1 Characterization of PGSA and PGSA-VAc co-polymer 42 3.2 Rheology and Viscosity Tests 44 3.3 Tensile Test 45 3.3.1 Ultimate Tensile Strength 45 3.3.2 Elongation at Break 47 3.3.3 Young’s Modulus 48 3.4 Thermal Tests 49 3.5 Glass Transition Temperature Measurement 50 3.6 Contact Angle 51 3.7 In-vitro Cell Culture 52 3.8 Degradation Tests 53 3.9 Swelling Tests 54 3.10 Digital Light Processing (DLP) 55 Chapter 4 Conclusion 56 Chapter 5 Future Work 56 Chapter 6 Reference 57

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