本論文主要目的是研究以具有叁鍵支鏈及丙二烯支鏈之α-碘基環酮化合物，進行離子化環化反應，合成螺旋環分子。利用本實驗室所發展的方法製備具有叁鍵支鏈之α-碘基環酮化合物35a-c1及丙二烯支鏈之 α-碘基環酮化合物38a-c2作為起始物，以三氯化鋁(AlCl3)媒介誘導離子化環化反應，順利得到具有七圓環的螺旋雙環產物36a-c、39a-c和40a-c。
此外，我們亦藉由控制溫度條件以促使丙二烯支鏈之α-碘基環酮化合物38a-c在進行離子化環化反應時能主要朝向動力學或熱力學反應之路徑，成功地控制環化產物的比例，並進一步深入的探討其可能 之反應機構。

This thesis is to study the ionic cyclization reaction of α-iodo cycloalkanones bearing an alkynyl side chain and an allenyl side chain , to get the spiro bicyclic products. We prepared the α-iodo cycloalkanones 35 a-c and 38 a-c as the starting materials developed in our laboratory, then via ionic cyclization reaction mediated by AlCl3. We can afford the 7-member ring of spiro bicyclic products 36 a-c, 39 a-c and 40 a-c successfully.
In addition, we can let the ionic cyclization of the α-iodo cycloalkanones 38 a-c proceed toward the dynamic or thermodynamic pathway by controlling the temperature and we can successfully control the ratios of the two types of products. We will propose the possible reaction mechanism.

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