光學同調斷層掃描儀(optical coherence tomography, OCT)是一種新發展的技術，且能夠產生高解析度的影像。系統的縱向解析度常常是決定於參考端與樣本端兩臂干涉波包訊號的半高全寬值(full width half maximum, FWHM)，但波包內有干涉強度的條紋變化，如果利用這些條紋的變化來做量測，那將會得到更好的縱向解析度。為了同時得到能夠測量較長範圍的光程變化測量以及高解析度的優點，我們利用低同調干涉波包的移動來測量折射率隨濃度的變化，以及用波包內的干涉條紋變化來測量折射率隨溫度的改變。實驗結果得到折射率與濃度呈現一個線性正比的關係，而折射率與溫度則呈現一個線性反比的關係。除了以上的測量外，我們還讓此儀器做更進一步的應用，來測量不同地區湖水中的折射率，藉著所測量到的折射率高低來評斷水質中的污染程度，提供一個新穎的檢測方式。

參考文獻
[1] S. H. Yun, G. J. Tearney, and B. E. Bouma, "Biomedical imaging using optical technologies," in Second European Workshop on Optical Fibre Sensors, 2004, pp. 17-24.
[2] E. J. Adams, D. S. Brettle, A. P. Jones, A. R. Hounsell, and D. J. Mott, "Estimation of fetal and effective dose for CT examinations," The British Journal of Radiology, vol. 70, pp. 272-278, 1997.
[3] M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. E. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, "Simultaneous PET-MRI: a new approach for functional and morphological imaging," Nat Med, vol. 14, pp. 459-65, Apr 2008.
[4] J. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, "Optical Coherence Tomography: An Emerging Technology for Biomedical Imaging and Optical Biopsy," Neoplasia, vol. 2, pp. 9-25, 2000.
[5] K. Grieve, A. Dubois, M. Simonutti, M. Paques, J. Sahel, L. Gargasson, Jean-Francois, and C. Boccara, "In vivo anterior segment imaging in the rat eye with high speed white light full-field optical coherence tomography," Opt. Express, vol. 13, pp. 6286-6295, 2005.
[6] M. Laubscher, M. Ducros, B. Karamata, T. Lasser, and R. Salathe, "Video-rate three-dimensional optical coherence tomography," Opt. Express, vol. 10, pp. 429-435, 2002.
[7] M. H. McCay, V. V. Semak, J. A. Hopkins, and B. Blaha, "Refractive index of NH4Cl–H2O as a function of wavelength: the effect of temperature and concentration," Appl. Opt., vol. 35, pp. 3715-8, 1996.
[8] L. Cheng, "A study on the tesing methods of hot spring water in Hell hot spring valley, Peitou," Chung Yuan Christian University Master thesis, 2004.
[9] D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science, vol. 254, pp. 1178-1181, 1991.
[10] W. F. Cheong, S. A. Prahl, and A. J. Welch, "A Review of the Optical Properties of Biological Tissues," IEEE, vol. 26, pp. 2166-2185, 1990.
[11] A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography principles and applications," Rep. Prog. Phys., vol. 66, pp. 239-303, 2003.
[12] P. H. Tomlins and R. K. Wang, "Theory, developments and applications of optical coherence tomography," J. Phys. D: Appl. Phys., vol. 38, pp. 2519-2535, 2005.
[13] W. Drexler, U. Morgner, F. X. Kartner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett., vol. 24, pp. 1221-1223, 1999.
[14] A. M. Kowalevicz, T. Ko, I. Hartl, and J. G. Fujimoto, "Ultrahigh resolution optical coherence tomography using a superluminescent light source," Opt. Express, vol. 10, pp. 349-353, 2003.
[15] C. Hitzenberger, P. Trost, P.-W. Lo, and Q. Zhou, "Three-dimensional imaging of the human retina by high-speed optical coherence tomography," Opt. Express, vol. 11, pp. 2753-61, 2003.
[16] A. L. Clark, A. Gillenwater, R. Alizadeh-Naderi, A. K. El-Naggar, and R. Richards-Kortum, "Detection and diagnosis of oral neoplasia with an optical coherence microscope," Journal of Biomedical Optics, vol. 9, pp. 1271-1280, 2004.
[17] H. Maruyama, S. Inoue, T. Mitsuyama, M. Ohmi, and M. Haruna, "Low-coherence interferometer system for the simultaneous measurement of refractive index and thickness," Appl. Opt., vol. 41, pp. 1315-1322, 2002.
[18] A. I. Kholodnykh, I. Y. Petrova, M. Motamedi, and R. O. Esenaliev, "Accurate Measurement of Total Attenuation Coefficient of Thin Tissue With Optical Coherence Tomography," IEEE, vol. 9, pp. 210-221, 2003.
[19] V. K. Chhaniwal, A. Anand, and C. S. Narayanamurthy, "Measurement of diffusion coefficient of transparent liquid solutions using Michelson interferometer," Optics and Lasers in Engineering, vol. 42, pp. 9-20, 2004.
[20] U. K. Krieger, J. C. Mossinger, B. Luo, U. Weers, and T. Peter, "Measurement of the refractive indices of H2SO4-HNO3-H2O solutions to stratospheric temperatures," Appl. Opt., vol. 39, pp. 3691-3703, 2000.
[21] A. M. Zysk, E. J. Chaney, and S. A. Boppart, "Refractive index of carcinogen-induced rat mammary tumours," Phys. Med. Biol., vol. 51, pp. 2165-2177, 2006.
[22] F. J. van der Meer, D. J. Faber, I. Cilesiz, M. J. C. van Gemert, and T. G. van Leeuwen, "Temperature-dependent optical properties of individual vascular wall components measured by optical coherence tomography," Journal of Biomedical Optics, vol. 11, pp. 041120-6, 2006.
[23] S. F. Chen, "Construction and Systematic Study of an Optical Coherence Microscopy," Master thesis, 2006.
[24] C. S. Yang, "Simultaneous measurement of refractive index and thickness of transparent materials by optical coherence tomography," Master thesis, 2006.
[25] E. Hecht, "Optics," pp. 386-389, 2002.
[26] J. M. Schmitt, "Optical Coherence Tomography (OCT): A Review," IEEE, vol. 5, pp. 1205-1215, 1999.
[27] B. E. A. Saleh and M. C. Teich, "Fundamentals of Photonics," pp. 350-351, 1991.
[28] 楊自森，吳見明，蔡旻龍，莊淳宇，崔豫笳，許志楧, "分子生醫光電科學與技術," 物理雙月刊, 2005.
[29] B. Richerzhagen, "Interferometer for measuring the absolute refractive index of liquid water as a function of temperature at 1.064 μm," Appl. Opt., vol. 35, pp. 1650-3, 1996.
[30] Y. Watanabe and I. Yamaguchi, "Digital Hilbert transformation for separation measurement of thicknesses and refractive indices of layered objects by use of a wavelength-scanning heterodyne interference confocal microscope," Appl. Opt., vol. 41, pp. 4497-4502, 2002.
[31] W. M. b. M. Yunus and A. b. A. Rahman, "Refractive index of solutions at high concentrations," Appl. Opt., vol. 27, pp. 3341-3343, 1988.
[32] K. V. Larin, T. Akkin, R. O. Esenaliev, M. Motamedi, and T. E. Milner, "Phase-sensitive optical low-coherence reflectometry for the detection of analyte concentrations," Appl. Opt., vol. 43, 2004.