研究生: |
謝其軒 Hsieh, Chi Hsuan |
---|---|
論文名稱: |
應用於生醫訊號特徵萃取及偵測之數位訊號處理系統 Design and Implementation of Digital Signal Processing Systems for Biomedical Features Extraction and Detection |
指導教授: |
黃元豪
Huang, Yuan Hao |
口試委員: |
伍紹勳
吳仁銘 楊家驤 蔡佩芸 馬席彬 鄭桂忠 朱大舜 |
學位類別: |
博士 Doctor |
系所名稱: |
電機資訊學院 - 通訊工程研究所 Communications Engineering |
論文出版年: | 2016 |
畢業學年度: | 104 |
語文別: | 英文 |
論文頁數: | 96 |
中文關鍵詞: | 超寬頻雷達 、呼吸信號 、腦電波 、人機介面 |
外文關鍵詞: | UWB, Respiration, EEG, BCI |
相關次數: | 點閱:2 下載:0 |
分享至: |
查詢本校圖書館目錄 查詢臺灣博碩士論文知識加值系統 勘誤回報 |
近來,由於穿戴式裝置的崛起以及老年人口比例的增加,整合式的生醫信號處理系統變得愈趨重要。在這篇論文當中,我們提出並實做了兩套先進的生醫數位信號處理系統。
生醫的信號處理基本上都可被歸類為特徵萃取以及偵測的問題。藉由合適的特徵萃取,我們在這篇論文當中發展了兩套高效率而低複雜度的生醫數位信號處理系統。第一套系統是一個利用眼動產生的腦波信號來控制電腦的腦機系統。我們利用了通訊系統常被使用的脈衝編碼解調演算法,實現了一個不需乘法器的眼動偵測系統。除此之外,我們還提出了針對這套演算法的訓練模型來調整演算法中會用到的參數。我們用FPGA實做了這套系統並且達到了百分之89.7的偵測率。
藉由這套系統,使用者可戴著腦波偵測儀器對下六種眼動的指令來控制電腦。
第二套系統則是一個基於超寬頻雷達的呼吸信號特徵萃取系統。在這套系統當中,我們提出了新的呼吸模型以及對應的特徵萃取演算法來偵測出除了呼吸頻率以外其他更多的呼吸特徵,例如吸氣速度,呼氣速度,呼吸深度,以及呼吸停等的時間比例等。這些特徵不只可用做醫學上評估診斷的潛在指標,它們同時也可以被視為壓縮後的呼吸模型信號,當我們只在意這些特徵時,每一次呼吸的記錄都可以只留下這些特徵,而省下長時間呼吸信號監測原本需要的大量儲存容量或是遠端照護中原本需要的傳輸頻寬。我們實做了一套實時的雷達呼吸信號特徵萃取平台,雷達呼吸信號由超寬頻雷達晶片送入我們的FPGA信號處理平台,信號處理平台再針對每一次的呼吸週期做信號處理並送出對應的特徵資料送至電腦上顯示。
Nowadays, the implementation of biomedical integrated systems are attracting more attention than before due to the emerging industry of wearable devices and the rapid growth
of elderly population. In particular, efficient biomedical signal processing systems are in demand for various applications. This dissertation aims to develop advanced digital signal processing (DSP) systems for wireless biomedical applications.
Many problems in the field of biomedical signal processing can be reduced to a task of feature extraction and event detection. This kind of problem generally treats a set of
measurements and asks for the recognition of some patterns. Through appropriate feature extraction from the targeted signal, we can develop efficient signal processing algorithms to perform different tasks. This dissertation proposes two digital signal processing biomedical systems. The first one is an electroencephalography (EEG) based brain-computer interface (BCI) utilizing eye commands. This system first uses a low-complexity edge detector to extract the sharp edges of the eye movement events. Then, we use pulse width demodulation (PWDM) to further classify the eye commands with only addition operations. Also, a training mechanism is proposed to facilitate the detection of eye commands. Users wearing an EEG headset can give six eye commands including glancing toward four directions and winking of the left or right eye. This proposed system is implemented with FPGA and
achieves a detection rate of 89.7% in the experiments.
The second proposed digital signal processing biomedical system is an ultra-wideband(UWB) radar signal processing platform for human respiratory feature extraction. In this
system, we propose a new respiration model and an iterative correlation search algorithm with early termination to acquire additional respiratory features such as the inspiration and expiration speeds, respiration intensity, and respiration holding ratio. These features, the parameterized and compressed respiratory signals, can provide physical information to facilitate clinical diagnosis and help to manage a more efficient database for the respiration monitoring system. The proposed respiratory feature extraction algorithm is designed and
implemented using the proposed UWB radar signal processing platform including a radar front-end chip and an FPGA chip. The proposed radar system can detect human respiration
rates at 0.1 to 1 Hz and facilitates the real-time analysis of the respiratory features of each respiration period. Moreover, the parameterized waveforms are used to construct a new diagnosis method for respiratory diseases in clinical trials.
[1] M. A. Hanson et al., “Body area sensor networks: challenges and opportunities,” Computer, vol. 42, no. 1, pp. 58–65, Jan. 2009.
[2] T. Calabria, “Software PACE detect with ADS1292,” in Texas Instruments, 2015.
[3] J. Malmivuo and R. Plonsey, Bioelectromagnetism: principles and applications of bioelectric and biomagnetic fields. Oxford University Press, 1995.
[4] A. Funase, T. Yagi, Y. Kuno, and Y. Uchikawa, “Prediction of eye movements from EEG,” in International Conference on Neural Information Processing, vol. 3, 1999, pp. 1127–1131.
[5] A. Funase, T. Hashimoto, T. Yagi, A. K. Barros, A. Cichocki, and I. Takumi, “Research for estimating direction of saccadic eye movements by single trial processing,” in 29th Int. Conf. IEEE Eng. Med. Biol. Soc.,, 2007, pp. 4723–4726.
[6] T. Ito, T. Shinji, H. Sumiya, and M. Baba, “Eye movement-related EEG potential pattern recognition for real-time BMI,” in Proceedings of SICE Annual Conference, 2010, pp. 1055–1059.
[7] S. S. Gupta, S. Soman, P. G. Raj, R. Prakash, S. Sailaja, and R. Borgohain, “Detecting eye movements in EEG for controlling devices,” in IEEE Conference on Computational Intelligence and Cybernetics, 2012, pp. 69–73.
[8] H. T. Nguyen, N. Trung, V. Toi, and V.-S. Tran, “An autoregressive neural network for recognition of eye commands in an EEG-controlled wheelchair,” in Int. Conf. on
Advanced Technologies for Communications, Oct. 2013, pp. 333–338.
[9] C.-W. Feng, T.-K. Hu, J.-C. Chang, and W.-C. Fang, “A reliable brain computer interface implemented on an FPGA for a mobile dialing system,” in IEEE Int. Symp. Circuits Syst., June 2014, pp. 654–657.
[10] Y. Zou and V. Nathan and R. Jafari, “Automatic Identification of Artifact-Related Independent Components for Artifact Removal in EEG Recordings,” IEEE J. Biomed. Health Inform., vol. 20, no. 1, pp. 73–81, Jan. 2016.
[11] C. H. Hsieh and Y. H. Huang, “Low-complexity EEG-based eye movement classification using extended moving difference filter and pulse width demodulation,” in IEEE Int. 37th Eng. Med. Biol. Conf., 2015, pp. 7238–7241.
[12] Y.-Y. Lin, “A sleep apnea detection algorithm using thoracic and abdominal movement signals,” in M.S. thesis, Department Electr. Eng., Nat. Tsing Hua Univ, Hsinchu, Taiwan, R.O.C 2014.
[13] E. Ja and W. Wa, “The assessment of maximal respiratory mouth pressures in adults,” J. Respir. Care., pp. 1348–1359, Oct. 2009.
[14] H. Jh et al., “Validation of the thoracic impedance derived respiratory signal using multilevel analysis,” Int. J. Psychophysiol., pp. 97–106, 2006.
[15] D. Teichmann et al et al., “The main shirt: a textile-integrated magnetic induction sensor array,” Int. J. Sensors, pp. 1039–1056, 2014.
[16] G. B. Moody et al., “Derivation of respiratory signals from multi-lead ECGs,” in Int. Conf. Computers in Cardiology, vol. 12, 1985, pp. 113–116.
[17] S. Ding et al et al., “Derivation of respiratory signal from single channel ECGs based on source statistics,” International Journal of Bioelectromagnetism, vol. 6, no. 1, 2004.
[18] C. Varon and S. Van Huffel, “ECG-derived respiration for ambulatory monitoring,” in Int. Conf. Computing in Cardiology, vol. Nice, 2015, pp. 169–172.
[19] F. Yasuma and J. Hayano, “Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm?” J. Chest, pp. 683–690, 2004.
[20] M. T. Valderas et al., “Human emotion recognition using heart rate variability analysis with spectral bands based on respiration,” in IEEE Int.37th Eng. Med. Biol. Conf., vol.
Milan, 2015, pp. 6134–6137.
[21] B. Venema et al., “Evaluating innovative in-ear pulse oximetry for unobtrusive cardiovascular and pulmonary monitoring during sleep,” IEEE Journal of Translational
Engineering in Health and Medicine, vol. 1, pp. 2700–2708, 2013.
[22] T.-S. Chu, J. Roderick, S.-H. Chang, T. Mercer, C. Du, and H. Hashemi, “A short-range UWB impulse-radio CMOS sensor for human feature detection,” in ISSCC Dig. Tech. Papers, Feb. 2011, pp. 294–296.
[23] M. Hussain, “Ultra-wideband impulse radar–an overview of the principles,” IEEE Aerosp. Electron. Syst. Mag., vol. 13, no. 9, pp. 9–14, 1998.
[24] G. Ossberger, T. Buchegger, E. Schimback, A. Stelzer, and R. Weigel, “Non-invasive respiratory movement detection and monitoring of hidden humans using ultra wideband
pulse radar,” in Proc. Int. Workshop Ultra Wideband Systems, 2004, pp. 395–399.
[25] E. Staderini, “UWB radar for patient monitoring,” IEEE Aerosp. Electron. Syst. Mag., vol. 23, no. 11, pp. 11–18, Nov. 2008.
[26] S. Wu et al., “Study on a novel UWB linear srray human respiration model and detection method,” IEEE Journal of Selected Topics in Applied Earth Observations and Remote
Sensing, vol. 9, no. 1, pp. 125–140, Jan. 2016.
[27] G. S. Chung, B. H. Choi, K. K. Kim, Y. G. Lim, J. W. Choi, D.-U. Jeong, and K. S. Park, “REM sleep Classification with respiration Rates,” in Conf. Rec. 6th Int. Special
Topic Conf. Inf. Tech. Applicat. Biomedicine, Nov. 2007, pp. 194–197.
[28] A. Tataraidze et al., “Sleep stage classification based on respiratory signal,” in IEEE Int. 37th Eng. Med. Biol. Conf., 2015, pp. 358–361.
[29] A. Lazaro, D. Girbau, and R. Villarino, “Analysis of vital signs monitoring using an IR-UWB radar,” in Proc. Progress Symp. Electromagnetics Research, vol. 100, 2010.
[30] F. Khan, J. W. Choi, and S. H. Cho, “Design issues in vital sign monitoring through IR UWB radar,” in 18th IEEE International Symposium on Consumer Electronics, 2014,
pp. 1–2.
[31] J. Yan, H. Zhao, Y. Li, L. Sun, H. Hong, and X. Zhu, “Through-the-wall human respiration detection using impulse ultra-wide-band radar,” in IEEE Topical Conference on
Biomedical Wireless Technologies, Networks, and Sensing Systems, 2016, pp. 94–96.
[32] M. Y. W. Chia, S. W. Leong, C. K. Sim, and K. M. Chan, “Throughwall UWB radar operating within FCCs mask for sensing heart beat and breathing rate,” in Proc. Eur.
Radar Conf., Oct. 2005, pp. 267–270.
[33] M. Baboli, S. A. Ghorashi, N. Saniei, and A. Ahmadian, “A new wavelet based algorithm for estimating respiratory motion rate using UWB radar,” in Proc. Int. Conf. Biomedical
Pharmaceutical Eng., Dec. 2009, pp. 1–3.
[34] M. Leib, W. Menzel, B. Schleicher, and S. Hermann, “Vital signs monitoring with a UWB radar based on a correlation receiver,” in Conf. Rec. 4th Eur. Conf. Antennas
Propagation, Apr. 2010, pp. 1–5.
[35] S. Kazemi, A. Ghorbani, H. Amindavar, and D. R. Morgan, “Vital-sign extraction using bootstrap-based generalized warblet transform in heart and respiration monitoring radar
system,” IEEE Transactions on Instrumentation and Measurement, vol. 65, no. 2, pp. 255–263, Feb. 2016.
[36] B. Oneda, K. C. Ortega, J. L. Gusmao, T. G. Araujo, and D. Mion Jr., “Sympathetic nerve activity is decreased during device-guided slow breathing,” in Hypertens Res., 2010, pp. 708–712.
[37] P. A. Derchak, A. W. Sheel, B. J. Morgan, D. F. Pegelow, and J. A. Dempsey, “Effects of expiratory muscle work on muscle sympathetic nerve activity,” in J. Applied Physiology, 2002.
[38] C.-H. Hsieh, Y.-H Shen, Y.-F. Chiu, T.-S. Chu, and Y.-H. Huang, “Human respiratory feature extraction on an UWB radar signal processing platform,” in Proc. IEEE Int. Conf. Circuits Syst., May 2013, pp. 1079–1082.
[39] C. H. Hsieh, Y. F. Chiu, Y. H. Shen, T. S. Chu and Y. H. Huang, “A UWB Radar Signal Processing Platform for Real-Time Human Respiratory Feature Extraction Based on Four-Segment Linear Waveform Model,” IEEE Trans. Biomed. Circuits Sys., vol. 10, no. 1, pp. 219–230, Feb. 2016.
[40] E. Niedermeyer and F. Silva, Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Lippincott Williams and Wilkins, 2004.
[41] T.-P. Jung, S. Makeig, M. Westerfield, J. Townsend, E. Courchesne, and T. J. Sejnowski, “Independent component analysis of single-trial event-related potentials,” in Proc. ICA’, Jan. 1999, pp. 173–178.
[42] M. Shahbakhti, M. Bavi, and M. Eslamizadeh, “Automatic removal of the eye blink artifact from EEG using an ICA-based template matching approach,” in International
Conference on Intelligent Systems Modelling and Simulation, Jan. 2013, pp. 190–194.
[43] K. J. Huang et al., “A real-time processing flow for ICA based EEG acquisition system with eye blink artifact elimination,” in IEEE Workshop on Signal Processing Systems,
Oct. 2013, pp. 237–240.
[44] S. Kanoga and Y. Mitsukura, “ICA-based positive semidefinite matrix templates for eye-blink artifact removal from EEG signal with single-electrode,” in 10th Asian Control Conference, 2015, pp. 1–6.
[45] R. Mahajan and B. I. Morshed, “Unsupervised Eye Blink Artifact Denoising of EEG Data with Modified Multiscale Sample Entropy, Kurtosis, and Wavelet-ICA,” IEEE J. Biomed. Health Inform., vol. 19, no. 1, pp. 158–165, Jan. 2015.
[46] L. W. Couch, Digital and analog communication systems. Prentice Hall, 2012.
[47] G. Repovs, “Dealing with noise in EEG recording and data analysis,” Informatica Medica Slovenica Journal, vol. 15, pp. 18–25, Jan. 2010.
[48] S. W. Smith, The Scientist and Engineer’s Guide to Digital Signal Processing. California Technical Pub., 1997.
[49] J. Canny, “A computational approach to edge detection,” IEEE Tran. Pattern Analysis and Machine Intelligence, vol. 8, no. 6, pp. 679–698, Nov. 1986.
[50] G. Strang and T. Nguyen, Wavelets and Filter Banks. Wellesley-Cambridge Press, 1996.
[51] M. Friese, “OFDM signals with low crest-factor,” in IEEE Global Telecommunications Conference, 1997, pp. 290–294.
[52] S. Kay, Fundamentals of Statistical Signal Processing Vol. II: Detection. Prentice Hall, 1998.
[53] H. Glencross et al., Biomedical Science Practice: Experimental and Professional Skills. Oxford University Press, 2010.
[54] A. Elisseeff and M. Pontil, “Leave-One-Out Error and Stability of Learning Algorithms with Applications,” in Advances in Learning Theory: Methods, Models and Applications, vol. 190, IOS Press, 2003.
[55] J. M. Kang et al., “Reliable estimation of respiration rate using UWB impulse radar,” in Proc. Asia-Pacific Microwave Conference, 2013, pp. 997–999.
[56] X. Huang, L. Sun, T. Tian, Z. Huang, and E. Clancy, “Real-time non-contact infant respiratory monitoring using UWB radar,” in IEEE 16th International Conference on
Communication Technology, 2015, pp. 493–496.
[57] J. G. Proakis, Digital Communications. McGraw-Hill, U.S.A., 2000.
[58] E. Vieth, “Fitting piecewise linear regression functions to biologicial responses,” in J. Appl. Physiol., vol. 67, Feb. 1989, pp. 390–396.
[59] R. S. L. Rabiner and C. Rader, “The chirp z-transform algorithm,” IEEE Trans. Audio Electroacoustics, vol. 17, no. 2, pp. 86–92, Jun. 1969.
[60] V. Kantabutr, “On hardware for computing exponential and trigonometric functions,” IEEE Trans. Comput.
[61] D.-U. Lee, A. A. Gaffar, O. Mencer, and W. Luk, “Adaptive range reduction for hardware function evaluation,” in Proc. Int. Conf. Field-Programmable Technol., Dec. 2004,
pp. 169–176.
[62] S. Khan, D. Bailey, G. S. Gupta, “Simulation of Triple Buffer Scheme (Comparison with Double Buffering Scheme),” in Conf. Rec. 2nd Int. Conf. Comput. Electr. Eng., vol. 2, Dec. 2009, pp. 403–407.
[63] C. Lomont, “Fast inverse square root,” in Department of Mathematics, Purdue University, Tech. Rep., Feb. 2003.
[64] A. Lazaro et al., “Vital signs monitoring using Impulse Based UWB Signal,” in 41st European Microwave Conf., Oct. 2011, pp. 135–138.
[65] S. I. Ivashov, V. V. Razevig, A. P. Sheyko, and I. A. Vasilyev, “Detection of human breathing and heartbeat by remote radar,” in Proc. Progress Symp. Electromagnetics
Research, Mar. 2004.
[66] Y.-S. Zhou, L. Kong, G.-L. Cui, and J.-Y. Yang, “Remote sensing of human body by stepped-frequency continuous-wave,” in Conf. Rec. 3rd Int. Conf. Bioinformatics Biomedical Eng., Jun. 2009, pp. 1–4.