本研究旨在探討有無動脈硬化樣本中，踝臂脈波傳導速率與心血管危險因子的差異。選取桃園地區某綜合醫院EBT心臟血管預防醫學中心的健康檢查個案為研究對象，依據醫師判斷為動脈硬化的標準，再經醫師同意取得研究對象性別、抽菸、年齡、身體質量指數、糖尿病、高血脂與高血壓等心血管危險因子的數值後，進行統計分析。統計方法有卡方檢定（Chi-square test）和獨立樣本t檢定（independent t-test）。本研究共取得288位有效樣本，平均年齡為55.22 ± 11.04歲，平均身高為166.28 ± 7.68公分，平均體重為69.95 ± 12.35公斤，其中動脈硬化樣本167人，無動脈硬化樣本121人。研究發現動脈硬化樣本的踝臂脈波傳導速率顯著高於無動脈硬化樣本；由心血管危險因子中，發現性別、抽菸、年齡、空腹血糖、三酸甘油酯和收縮壓等，有無動脈硬化樣本間有顯著差異，且三酸甘油酯為較重要的因子，建議可透過運動減少血中三酸甘油酯的含量，以延緩動脈硬化的可能發展。

The purpose of this study were to investigate the significance between brachial-ankle pulse wave velocities (baPWV) and cardiovascular risk factors in subjects with and without atherosclerosis. Subjects were recruited from EBT Cardiovascular Preventive Medicine Center at a hospital in Tao-Yuan. At first, according to the criteria diagnosed by the doctor, we classified subjects into two groups (with and without atherosclerosis). Second, we received the permission to collect the data of cardiovascular risk factors, including gender, smoking, age, body mass index, diabetes mellitus, high blood cholesterol, and high blood pressure. Besides, we also obtained the informed consent from the doctor. Third, we investigated the significance of difference between two groups, followed by Chi-square test and independent t-test. Results showed that: (a) there were 288 subjects whose average age was 55.22 ± 11.04 yr, average height was 166.28 ± 7.68 cm, and average weight was 69.95 ± 12.35 kg. And there were 167 subjects with atherosclerosis and 121 subjects without atherosclerosis. (b) baPWV was significantly higher in subjects with atherosclerosis than those without. (c) Among these cardiovascular risk factors, gender, smoking, age, fasting blood glucose, triglyceride, and systolic blood pressure had significant difference in subjects with and without atherosclerosis. Therefore, this study concluded and suggested that: (a) Triglyceride was more important risk factor for atherosclerosis. (b) We could exercise more often to reduce the amount of triglyceride. And by this way, we could reduce the possibility of atherosclerosis.

行政院衛生署(2002年4月15日)。國人肥胖定義及處理原則出爐【公告】。
臺北市：行政院衛生署。2007年5月26日，取自：http://www.doh.gov
.tw/CHT2006/DM/SEARCH_MAIN.aspx?keyword=%u80a5%u80d6%u5b
9a%u7fa9.
死因統計（96年版）【資料檔】。臺北市：行政院衛生署。
高血脂防制手冊（96年版）【資料檔】。臺北市：行政院衛生署國民健
康局。
American Diabetes Association. (2006). Standards of medical care in diabetes-2006. Diabetes Care, 29(5), S4-S42.
American Heart Association. (2001). Risk factors and coronary artery disease. Statistical 2001 update. Dallas: Texas.
American Heart Association. (2007). Heart disease and stroke statistics. 2007 update at-a-glance. Dallas: Texas.
Auerbach, O., Carter, H. W., Garfinkel, L., & Hammond, E. C. (1976). Cigarette smoking and coronary artery disease. Chest, 70(6), 697-705.
Aznaouridis, K., Vlachopoulos, C., Dima, I., Ioakeimidis, N., & Stefanadis, C. (2007). Triglyceride level is associated with wave reflections and arterial stiffness in apparently healthy middle-aged men. Heart, 93, 613-614.
Benetos, A., Adamopoulos, C., Bureau, J. M., Temmar, M., Labat, C., Bean, K., et al. (2002). Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period. Circulation, 105(10), 1202-1207.
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., et al. (2003). The seventh report of the joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. The Journal of the American Medical Association, 289(19), 2560-2572.
Choi, K. M., Lee, K. W., Seo, J. A., Oh, J. H., Kim, S. G., Kim, N. H., et al. (2004). Relationship between brachial-ankle pulse wave velocity and cardiovascular risk factors of the metabolic syndrome. Diabetes Research and Clinical Practice, 66(1), 57-61.
Creager, M. A., Dazu, V. J., & Loscalzo, J. L. (2006). Vascular medicine: A companion to Braunwald’s heart disease. Philadelphia: Elsevier.
Jatoi, N. A., Jerrard-Dunne, P., Feely, J., & Mahumd, A. (2007). Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension. Hypertension, 49(5), 981-985.
Kim, J. W., Park, C. G., Hong, S. J., Park, S. M., Rha, S. W., Seo, H. S., et al. (2005). Acute and chronic effects of cigarette smoking on arterial stiffness. Blood Pressure, 14(2), 80-85.
Loukogeorgakis, S., Dawson, R., Phillips, N., Martyn, C. N., & Greenwald, S. E. (2002). Validation of a device to measure arterial pulse wave velocity by a photoplethysmographic method. Physiological Measurement, 23(3), 581-596.
Mahmud, A., & Feely, J. (2003). Effect of smoking on arterial stiffness and pulse pressure amplification. Hypertension, 41(1), 183-187.
Meijer, W. T., Grobbee, D. E., Hunink, M. G., Hofman, A., & Hoes, A. W. (2000). Determinants of peripheral arterial disease in the elderly: the Rotterdam study. Archives of Internal Medicine, 160(19), 2934-2938.
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (2002). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 106(25), 3227-3421.
Ohnishi, H., Saitoh, S., Takagi, S., Ohata, J. I., Isobe, T., Kikuchi, Y., et al. (2003). Pulse wave velocity as an indicator of atherosclerosis in impaired fasting glucose. Diabetes Care, 26, 437-440.

Rhee, M. Y., Na, S. H., Kim, Y. K., Lee, M. M., & Kim, H. Y. (2007). Acute effects of cigarette smoking on arterial stiffness and blood pressure in male smokers with hypertension. American Journal of Hypertension, 20(6), 637-641.
Tomiyama, H., Yamashina, A., Arai, T., Hirose, K., Koji, Y., Chikamori, T., et al. (2003). Influence of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement－a survey of 12,517 subjects. Atherosclerosis, 166(2), 303-309.
Yamashina, A., Tomiyama, H., Tekeda, K., Tsuda, H., Arai, T., Hirose, K., et al. (2002). Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertension Research, 25(3), 359-364.