中國人長久歷史的經驗累積中有所謂的「醫食同源」，這句話具體表達了中國傳統的醫學基本觀念，因此，除了西醫療法外，人們常常會嘗試以中草藥進補，以期能增加身體的抵抗力及達到改變身體機能之功效。本論文中，我們在C57BL/6J小鼠皮下植入攝護腺腫瘤細胞株TRAMP-C1來模擬癌症的產生，再仿效傳統中草藥經由口服的投藥方式，以餵食管餵食小鼠冬蟲夏草、茯苓及裂褶菌水萃液，觀察餵食中草藥對小鼠體內腫瘤生長的影響。此外，我們並以三種中草藥水萃液餵食正常小鼠，再去探討冬蟲夏草、茯苓、裂褶菌是否可以影響正常小鼠的免疫系統。實驗發現，茯苓及裂褶菌水萃液在體外實驗可以直接抑制TRAMP-C1細胞株的生長，而餵食帶有TRAMP-C1腫瘤小鼠冬蟲夏草、茯苓及裂褶菌水萃液能夠有效的延緩腫瘤的生長速率；並且能夠活化部份的免疫機能，刺激脾臟細胞的活性，使IFN-γ的分泌量增加，進而去活化免疫系統。因此，冬蟲夏草、茯苓及裂褶菌水萃液可以抑制初生腫瘤的生長，並可調節正常小鼠的免疫系統。

Medicinal fungi of traditional Chinese medicine have been widely used as tonic food and herbal medicine since ancient times in China. This research aimed to establish an animal system to evaluate the immunomodulation and anti-tumor activity of Chinese herbal medicine. In the literature, we were intrigued in whether Cordyceps sinensis, Poria cocos, and Schizophyllum commune could enhance the immunity and be an effective anti-tumor agent. The prostate cancer cell line, TRAMP-C1, was injected into C57BL/6J mice subcutaneously, and the water extracts of herbal medicine mentioned above were then orally administered to testify for the anti-tumor effect. Regarding the potential influences on immune function in mice, normal mice were fed with the water extracts of herbal medicine to evaluate certain targets of immunity. The results demonstrated that tumor-bearing mice treated with the water extracts of herbal medicine had a significant effect on tumor-growth delay. The mice orally administered the water extracts, in addition, activated partial immune functions, including IFN-γ, which might be an effective activator of macrophages, secreted by spleenocytes. The above suggested Cordyceps sinensis, Poria cocos, and Schizophyllum commune were efficient agents against tumor progression and served as potential immunomodulators.

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