近年來油價攀升、環保意識高漲，發展替代能源為各國致力的主要目標。生質能源為目前可以取代石化柴油的主要替代能源，然而目前已商業化的傳統鹼製程，尚存在一些缺陷，如反應完需加入酸液以中和鹼觸媒，另外需要水洗去鹼離子而產生大量廢水。此外，反應後續處理需額外設備將未反應的甲醇蒸餾，將增加環境負擔及生產成本。
本研究利用固體觸媒在半批次反應系統進行大豆油之轉酯化反應，在反應中持續通入甲醇，由於操作溫度大於甲醇沸點，甲醇會以氣泡型式通過反應器，有助於甲醇與大豆油之間的混合及反應，順帶夾帶走對於轉酯化反應有抑制作用的水分，以提高甲基酯的產率。
本研究挑選經批次反應系統測試反應性較佳的Ba(NO3)2/ZnO及SrO觸媒，利用此兩種觸媒在半批次反應系統中進行轉酯化反應，探討觸媒含量、甲醇流量、溫度、定量幫浦流量對於甲基酯產率的影響。實驗結果顯示，由於Ba(NO3)2燒結於載體的量較少，因此活性點的量較少，且由於質傳因素使得Ba(NO3)2/ZnO在半批次反應系統的反應性不及批次反應系統。而利用SrO觸媒則發現在觸媒含量3 %、甲醇流量0.8 ml/min、溫度65 ℃、定量幫浦流量520 ml/min的較適參數條件下，可在反應進行60分鐘後達98 %的甲基酯產率，大於批次反應系統在類似條件下的93 %甲基酯產率 (觸媒含量3 %、溫度65℃、醇油比5.83、攪拌器轉速300 rpm)。

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