Poly(amidoamine) Dendrimer大約在1984年由D. A. Tomalia等人所發現的一種新型的聚合物 , 它具有單一分子量分佈(monodispersity)、具多孔性的內部、高溶解度、低黏度及結構設計多樣化等優點 , 這對於醫藥、生物科技、光學等領域而言都有很大的潛力 , 因此近10年來很受到科學家的重視。
本篇論文的研究重點在於將dendrimer長在矽基材上後 , 觀察dendrimer相對於各種環境條件所產生的變化 ; 探討以不同溫度加熱、浸泡於不同濃度的酸鹼溶液及不同種類的有機溶劑中 , 來觀察dendrimer物理及化學性質的改變 ; 由於自組裝在矽基材上的dendrimer無法以電子顯微鏡或是現行的各種儀器直接觀察 , 因此研究的方法是藉由奈米金粒子會和胺基相結合的原理 , 間接地來觀察dendrimer在各種環境條件下的變化 , 並以此作為將來發展實驗晶片的基礎。

The poly(amidoamine) dendrimer is a new type polymer which discovered by D. A. Tomalia et al. in 1984. The dendrimer has attracted scientist’s attention for the past decades. It possesses some important advantages, like monodispersity, porosity, high aqueous resolution, low viscosity, variety of structure design, and has a number of potential applications for medical science, biotechnology and optics science yet.
The key points of investigation are to study the chemical change of dendrimer under various conditions. The physical and chemical properties are investigated for the different heating temperature, immersing in the different concentration of acid and basic solution, as well as in the various kinds of organic solvent. Since the morphology of dendrimer self-assembling on the silicon wafer can not be directly observed by electronic microscopy or by current instrument, the developed method of research is to indirectly observe the density changes by way of gold nanoparticle binding with amine functional groups on the substrate under the kinds of conditions, different heating temperature, immersing in the different concentration of acid and basic solution. The study can as also used ad the basis of developing lab-on-chip (LOC).

參考文獻

1. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.xxxvi, Great Britain(2001)
2. Elias, H.-G. Mega Molecules, Springer-Verlag, Berlin. (1987).
3. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.8, Great Britain(2001)
4. http://inventors.about.com/library/inventors/blpolystyrene.htm
5. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.9, Great Britain(2001)
6. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.9, Great Britain(2001)
7. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.9, Great Britain(2001)
8. Z. Guan, P. M. Cotts, E. F. McCord, S. J. McLain, Science, 283, 2059(1999)
9. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.10, Great Britain(2001)
10. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.10, Great Britain(2001)
11. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.14-16, Great Britain(2001)
12. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.16, Great Britain(2001)
13. Gauthier, M. and Moller, “Uniform highly branched polymers by anionic grafting: arborescent graft polymers”, Macromolecules, 24, 4548(1991)
14. Tomalia, D. A., Hedstrand, D. M. and Ferrito, M. S. “Comb-Burst Dendrimer Topology. New Macromolecular Architecture Derived from Dendritic Grafting”, Macromolecules, 24, 1435(1991)
15. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.15, Great Britain(2001)
16. http://www.c-science.com/txt/tc/te/em/980129teem.htm
17. http://www.newton.com.tw/e-paper/epaper65.htm
18. http://www.qsl.net/vr2xbp/nano/nanotech-07.html
19. http://www.google.com.tw/search?q=cache:G2h_IUcUMgYJ:www.st-pioneer.org.tw/%E5%85%A7%E6%96%87%E9%A0%81/it018/p15.html+dendrimer&hl=zh-TW&lr=lang_zh-TW&ie=big5&inlang=zh-TW
20. http://www.st-pioneer.org.tw/modules.php?name=magazine&pa=showpage&tid=319
21. N. Toshima, T. Yonezawa, “Bimetallic Nanoparticles-Novel Materials for Chemical and Physical Application” , New J. Chem., 22, 1179(1998)
22. 張育誠, “研究微波加熱技術在奈米材料之合成、自組裝及分解機構”, 國 立清華大學碩士論文, 2003
23. M. T. Reetz, W. Helbig, S. A.Quaiser, “Electrochemical Preparation of Nanostructural Bimetallic Clusters” , Chem.Mater., 7, 2227(1995)
24. 王鉦源，“以化學還原法製備奈米級銀鈀微粉”，國立成功大學碩士論文 , 2002
25. F. Kim, J. H. Song, P. Yang, “Photochemical Synthesis of Gold Nanorods” , J. Am. Chem. Soc., 124, 14316(2002)
26. M. Y. Han, C. H. Quek, “Photochemical Synthesis in Formamide and Room- Temperature Coulomb Staircase Behavior of Size-Controlled Gold Nanoparticles”, Langmuir., 16, 362(2000)
27. L. Rivas, S. S. Cortes, J. V. G. Ramos, G. Morcillo, “Growth of Silver Colloidal Particles Obtained by Citrate Reduction To Increase the Raman Enhancement Factor” , Langmuir., 17, 574(2001)
28. S. Link, Z. L. Wang, M. A. E. Sayed, “Alloy Formation of Gold-Silver Nanoparticles and the Dependence of the Plasmon Absorption on Their Composition” , J. Phys. Chem. B., 103, 3529(1999)
29. A. B. R. Mayer, J. E. Mark ,“Poly(2-hydroxyalkyl methacrylates) as Stabilizers for Colloidal Noble Metal Nanoparticles” , Polymer., 41, 1627(2000)
30. N. Toshima, M. Harada, Y. Yamazaki, K. Asakura, “Catalytic Activity and Structural Analysis of Polymer-Protected Gold-Palladium Bimetallic Clusters Prepared by The Simultaneous Reduction of Hydrogen Tetrachloroaurate and Palladium Dichloride” , J. Phys. Chem., 96, 9927(1992)
31. http://www.devicelink.com/ivdt/archive/00/03/004.html
32. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.24, Great Britain(2001)
33. G. R. Newkome, E. He, C. N. Moorefield, “Suprasupermolecules with Novel properties Metallodendrimers”, Chem. Rev., 99, 1689(1999)
34. G. R. Newkome, E. He, C. N. Moorefield, “Dendrimers and Dendrons”, WILEY-VCH, p.52, Germany(2001)
35. G. R. Newkome, E. He, C. N. Moorefield, “Dendrimers and Dendrons”, WILEY-VCH, p.191, Germany(2001)
36. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.34, Great Britain(2001)
37. Li Zhou, David H. Russell, Mingqi Zhao, and Richard M. Crooks, “Characterization of Poly(amidoamine) Dendrimers and Their Complexes with Cu2+ by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry”, Macromolecules, 34, 3567(2001)
38. T. H. Mourey, S. R. Turner, M. Rubinstein, C. J. Hawker, K. L. Wooley, Macromolecule, 25, 2401(1992)
39. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.35, Great Britain(2001)
40. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.28, Great Britain(2001)
41. John Scheirs, “Dendrimers and Other Dendritic Polymers”, Wiley Series in Polymer Science, p.29, Great Britain(2001)
42. Giovanni Nisato, Robert Ivkov, and Eric J. Amis, “Size Invariance of Polyelectrolyte Dendrimers”, Macromolecules, 33, 4172(2000)
43. P. Welch, M. Muthukumar, “Tuning the Density Profile of Dendritic Polyelectrolytes”, Macromolecules, 31, 5892(1998)
44. D. A. Tomalia, H. Baker, J. Dewald, M.Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder, and P. Smith, “A New Class of Polymers: Starburst-Dendritic Macromolecules”, Polymer Journal, 17, 117(1985)
45. Brandon Yoza, Atsushi Arakaki, Tadashi Matsunaga, “DNA extraction using bacterial magnetic particles modified with hyperbranched polyamidoamine dendrimer”, Journal of Biotechnology, 101, 219(2003)
46. Wei Chen, Donald A. Tomalia, and James L. Thomas, “Unusual pH-Dependent Polarity Changes in PAMAM Dendrimers: Evidence for pH-Responsive Conformational Changes”, Macromolecules, 33, 9169(2000)
47. Giovanni Nisato, Robert Ivkov, and Eric J. Amis, “Structure of Charged Dendrimer Solutions As Seen by Small-Angle Neutron Scattering”, Macromolecules, 32, 5895(1999)