研究生: |
賴佩伶 Lai, Pei-Ling |
---|---|
論文名稱: |
介入性血管攝影劑量評估系統之建立:應用於經動脈肝腫瘤栓塞 Establishing Dose Evaluation System for Interventional Angiography : Transcatheter Arterial Embolization |
指導教授: |
莊克士
Chuang, Keh-Shih 蔡惠予 Tsai, Hui-Yu |
口試委員: | |
學位類別: |
碩士 Master |
系所名稱: |
原子科學院 - 核子工程與科學研究所 Nuclear Engineering and Science |
論文出版年: | 2010 |
畢業學年度: | 98 |
語文別: | 中文 |
論文頁數: | 78 |
中文關鍵詞: | 經動脈肝腫瘤栓塞術 、自顯色膠片 、蒙地卡羅模擬 、有效劑量 |
外文關鍵詞: | Transcatheter arterial embolization, Gafchromic film, Measurement-based Monte Carlo simulation, Effective dose |
相關次數: | 點閱:2 下載:0 |
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影像導引式手術利用透視導引執行醫療程序,因為容易達到病灶且相對風險小,越來越廣泛使用,成功地治療許多疾病,然而卻存在確定性效應和機率性效應的風險。國際組織也對於介入性的放射手術有閾值劑量上的建議,和皮膚劑量的限值。
本研究利用自顯色膠片和蒙地卡羅程式BEAMnrcMP建立一套評估劑量的方法,對此模型的射束品質、劑量特性進行驗證,並將完成膠片輻射劑量計量測病人表面劑量之結果放入蒙地卡羅模擬,進行決定劑量轉換,進而計算器官組織劑量。
本系統已成功建立,已可評估經動脈肝腫瘤栓塞手術時,個別病人的器官劑量和有效劑量,未來也可將此系統應用於其他介入性手術,這個系統的建立與運用極具意義,在臨床上的建議及學術上的研究具有相當的價值。
Minimally invasive imaging-guided vascular interventions with fluoroscopy and digital subtraction angiographic have recently become widespread and have been successfully in the treatment of various diseases. However, interventional fluoroscopy procedures may present deterministic and stochastic radiation risks. The International Commission on Radiological Protection (ICRP) and the Food and Drug Administration have requested identification of procedures that may involve patient doses greater than the recommended threshold.
In this study, we used the gafchromic dosimetric media (self-developing “film”) and Measurement-based Monte Carlo simulation to establish the dose evaluation system for transcatheter arterial embolization of interventional radiology. We investigated the beam quality, characteristics of gafchromic films and further, and successfully inputed dose distribution of the measured films from clinical situation to Monte Carlo simulation. We calculated the organ doses and eventually get the effective doses.
Establishing the dose evaluation system for transcatheter arterial embolization to investigate the organ and effective doses has provided the good experiences to other applications.
Bacher K, Smeets P, Vereecken L, De Hauwere A, Duyck P, De Man R, Verstraete K and Thierens H 2006 Image Quality and Radiation Dose on Digital Chest Imaging: Comparison of Amorphous Silicon and Amorphous Selenium Flat-Panel Systems Am. J. Roentgenol. 187 630-7
Balter S 2006 Methods for measuring fluoroscopic skin dose Pediatric Radiology 36 136-40
Balter S 2008 Capturing patoent doses from fluoroscopically based diagnostic and interventional systems Health Phys 95 535-40
Betsou S, Efstathopoulos E P, Katritsis D, Faulkner K and Panayiotakis G 1998 Patient radiation doses during cardiac catheterization procedures Br J Radiol 71 634-9
Blair A and Meyer J 2009 Characteristics of Gafchromic[sup [registered sign]] XR-RV2 radiochromic film Medical Physics 36 3050-8
Bor D, Olg˘ar T, Toklu T r, C﹐ag˘lan A a, O‥nal E and Padovani R 2009 Patient doses and dosimetric evaluations in interventional cardiology Physica Medica 25 31-42
Bozkurt A and Bor D 2007 Simultaneous determination of equivalent dose to organs and tissues of the patient and of the physician in interventional radiology using the Monte Carlo method Phys. Med. Biol. 52 317-30
C.-M. Ma, C. W. Coffey, L. A. DeWerd, C. Liu, R. Nath, S. M. Seltzer and J. P. Seuntjens 2001 AAPM protocol for 40–300 kV x-ray beam dosimetry in radiotherapy and radiobiology Med. Phys. 28 26
D'Ercole L, Mantovani L, Thyrion F Z, Bocchiola M, Azzaretti A, Di Maria F, Saluzzo C M, Quaretti P, Rodolico G, Scagnelli P and Andreucci L 2007 A Study on Maximum Skin Dose in Cerebral Embolization Procedures AJNR Am J Neuroradiol 28 503-7
Dragusin O, Smans K, Jacobs J, Inal T and Bosmans H 2008 Evaluation of the contrast-detail response of a cardiovascular angiography system and the influence of equipment variables on image quality. ed H Jiang and S Ehsan: SPIE) p 69134R
El-Serag HB M J, Rudolph L, Reddy KR 2008 Diagnosis and Treatment of Hepatocellular Carcinoma GASTROENTEROLOGY 134 1752–63
G Drexler, W Panzer, L Widenmann, G Williams and Zankl M 1984 The Calculation of Dose from External Photon Exposures Using Reference Human Phantoms and Monte Carlo Methods Part III: Organ Doses in X-Ray Diagnosis GSF-Bericht S-1026
IAEA-TECDOC-1641 2010 Patient dose optimization in fluoroscopically guided interventional procedures. Radiation Safety and Monitoring Section International Atomic Energy Agency Vienna International Centre)
ICRP 2000 Avoidance of radiation injuries from medical interventional procedures ICRP Publication 85. International Commission on Radiological Protection)
ICRP 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. International Commission on Radiological Protection)
Jones H E and Cunningham J R 1983 The physics of radiology. Charles C. Thomas)
Kosunen A, Komppa T and Toivonen M 2005 Evaluation of methods to estimate the patient dose in interventional radiology Radiat Prot Dosimetry 117 178-84
Kotter E and Langer M 2002 Digital radiography with large-area flat-panel detectors Eur Radiol 12 2562-70
Kyriakou Y, Richter G, Dorfler A and Kalender W A 2008 Neuroradiologic Applications with Routine C-arm Flat Panel Detector CT: Evaluation of Patient Dose Measurements AJNR Am J Neuroradiol 29 1930-6
Lin M-H, Chao T-C, Lee C-C, Tung C-J, Yeh C-Y and Hong J-H 2009 Measurement-based Monte Carlo dose calculation system for IMRT pretreatment and on-line transit dose verifications Medical Physics 36 1167-75
Lin P-J P 2007 The operation logic of automatic dose control of fluoroscopy system in conjunction with spectral shaping filters Med Phys 34 3169-72
Lin P J 2008 Technical advances of interventional fluoroscopy and flat panel image receptor Health Phys 95 650-7
Livingstone R S and Mammen T 2005 Evaluation of radiation dose to patients during abdominal embolizations Indian Journal of Medical Sciences 59 528-34
LK Wagner P 2007 Radiation injury is a potentially serious complication to fluoroscopically-guided complex interventions Biomedical Imaging and Intervention Journal 3 e22
Mahesh M 2001 Fluoroscopy: Patient Radiation Exposure Issues Radiographics 21 1033-45
Mantovani L, D'Ercole L, Lisciandro F, Quaretti P, Azzaretti A, Rodolico G, Saluzzo C M, Spinazzola A, Di Maria F, Ottolenghi A, Thyrion F Z and Andreucci L 2006 Radiochromic Films for Improved Evaluation of Patient Dose in Liver Interventions J Vasc and Interv Radiol 17 855-62
McParland B 1998 Entrance skin dose estimates derived from dose-area product measurements in interventional radiological procedures Br J Radiol 71 1288-95
Miller D L 2008 Radiation injury is potentially a severe consequence of fluoroscopically guided complex interventions Health phys 95 645-9
Nickoloff E L, Lu Z F, Dutta A, So J, Balter S and Moses J 2007 Influence of flat-panel fluoroscopic equipment variables on cardiac radiation doses Cardiovasc. Interv. Radiol. 30 169-76
Omrane L B, Verhaegen F, Chahed N and Mtimet S 2003 An investigation of entrance surface dose calculations for diagnostic radiology using Monte Carlo simulations and radiotherapy dosimetry formalisms Phys. Med. Biol. 48 1809–24
Perz J F, Armstrong G L, Farrington L A, Hutin Y J F and Bell B P 2006 The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide Journal of Hepatology 45 529-38
Purcell R H 1993 The discovery of the hepatitis viruses. Gastroenterology 104:955-63.
Rassow S 1998 From the Entrance Dose to the Calculation of Organ Doses Radiat Prot Dosimetry 80 327-9
Rosario F. Vel’azquez, Manuel Rodrı’guez , Carmen A. Navascu’es, Antonio Linares , Ram’on P’erez , Nieves G. Sotorrı’os, Isabel Martı’nez and Rodrigo L 2003 Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis Hepatology 37 520-7
RP B 1988 Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61 1942-56
Ryder S D 2003 Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults Gut 52
Smans K, Struelens L, Hoornaert M-T, Bleeser F, Buls N, Berus D, Clerinx P, Malchair F, Vanhavere F and Bosmans H 2008 A study of the correlation between dose area product and effective dose in vascular radiology Radiat Prot Dosimetry 130 300-8
Stratakis J, Damilakis J, Tsetis D and Gourtsoyiannis N 2007 Radiation dose and risk from fluoroscopically guided percutaneous transluminal angioplasty and stenting in the abdominal region Eur Radiol 17 2359-67
Strotzer M, Volk M, Wild T, von Landenberg P and Feuerbach S 2000 Simulated Bone Erosions in a Hand Phantom: Detection with Conventional Screen-Film Technology versus Cesium Iodide-Amorphous Silicon Flat-Panel Detector Radiology 215 512-5
Suzuki S, Furui S, Kobayashi I, Yamauchi T, Kohtake H, Takeshita K, Takada K and Yamagishi M 2005 Radiation Dose to Patients and Radiologists During Transcatheter Arterial Embolization: Comparison of a Digital Flat-Panel System and Conventional Unit Am. J. Roentgenol. 185 855-9
Suzuki S, Furui S, Yamaguchi I, Yamagishi M, Abe T, Kobayashi I and Haruyama T 2008 Entrance Surface Dose during Three-dimensional Imaging with a Flat-panel Detector Angiography System Journal of Vascular and Interventional Radiology 19 1361-5
Suzuki S, Furui S, Yamaguchi I, Yamagishi M, Watanabe A, Abe T and Kobayashi I 2009 Effective dose during abdominal three-dimensional imaging with a flat-panel detector angiography system Radiology 250 545-50
Tsapaki V, Ahmed N A, AlSuwaidi J S, Beganovic A, Benider A, BenOmrane L, Borisova R, Economides S, El-Nachef L, Faj D, Hovhannesyan A, Kharita M H, Khelassi-Toutaoui N, Manatrakul N, Mirsaidov I, Shaaban M, Ursulean I, Wambani J S, Zaman A, Ziliukas J, Zontar D and Rehani M M 2009 Radiation Exposure to Patients During Interventional Procedures in 20 Countries: Initial IAEA Project Results Am. J. Roentgenol. 193 559-69
Vano E, Jarvinen H, Kosunen A, Bly R, Malone J, Dowling A, Larkin A, Padovani R, Bosmans H, Dragusin O, Jaschke W, Torbica P, Back C, Schreiner A, Bokou C, Kottou S, Tsapaki V, Jankowski J, Papierz S, Domienik J, Werduch A, Nikodemova D, Salat D, Kepler K, Bor M D, Vassileva J, Borisova R, Pellet S and Corbett R H 2008 Patient dose in interventional radiology: a European survey Radiat Prot Dosimetry 129 39-45
Victorian State Government D o H, Australia 2007 Radiation Safety Standard: Fluoroscopic X-ray equipment. Victorian Government Department of Human Service Melbourne, Victoria)
Walters B, Kawrakow I and Rogers D W O 2009 DOSXYZnrc Users Manual Ionizing Radiation Standards National Research Council of Canada
Wielandts J-Y and et al. Effective dose analysis of three-dimensional rotational angiography during catheter ablation procedures Physics in Medicine and Biology 55 563
江謝鎮至 2008 使用蒙地卡羅方法評估多切面電腦斷層掃描劑量:假體研究. 國立清華大學碩士論文