研究生: |
盧勇發 |
---|---|
論文名稱: |
氣相沉積鑽石晶片應用於加馬(Cs-137)血品照射儀之劑量分布量測 The Measurement of Chemical Vapor Deposition Diamond Films for Gamma (Cs-137) Blood- Irradiator dose distribution |
指導教授: |
朱鐵吉
邱志宏 游澄清 |
口試委員: | |
學位類別: |
碩士 Master |
系所名稱: |
原子科學院 - 生醫工程與環境科學系 Department of Biomedical Engineering and Environmental Sciences |
論文出版年: | 2005 |
畢業學年度: | 93 |
語文別: | 中文 |
論文頁數: | 63 |
中文關鍵詞: | 血品照射儀 、移殖反宿主病 、CVD鑽石薄膜 、劑量分布 |
外文關鍵詞: | blood irradiator, graft-versus-host-disease, CVD diamond film, dose distribution |
相關次數: | 點閱:2 下載:0 |
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近年來輸血後移植反宿主疾病(GVHD)是骨隨移植和器官移植最多致死的合併症。所以,要輸給免疫缺乏症病人之各種血品,必須先施以15~50 Gy輻射照射劑量,破壞血品中淋巴球的免疫能力,以避免輸血後GVHD的發生。由於國內、外漸漸的在血品照射方面,以可直接放置於血庫的加馬(Cs-137)血品照射儀取代直線加速器;因此對於加馬血品照射儀照射的劑量品質、劑量分布,建立血品的劑量品質控制標準及確保病患輸血安全便顯得刻不容緩。。
化學氣相沉積法產生的鑽石薄膜,其熱發光的輝光曲線及其動力學的特性,已有多位研究人員發表其研究成果,展現其在能量100 keV-2 MeV間無能量依存性。所以本文的主軸在使用CVD鑽石薄膜作為高輻射劑量的量測工具。量測MDS Nordion’s Gammacell血品照射儀的樣本容器內照射血品實際接受的劑量分布與照射中心點的吸收劑量。
由分析結果顯示CVD鑽石薄膜的吸收劑量回應曲線在高劑量區(5- 30 Gy)有良好的線性(R-square為0.9853);實驗證實在不同射源(Co-60與Cs-137)間無能量依存性。本實驗照射時間設定為樣本容器中心點接受25 Gy的劑量,與原廠劑量分布的數據比較時,顯示受照射血品實際接受的平均吸收劑量(27.9 Gy)與照射中心點(26 Gy)的吸收劑量都較原廠設定值高約4 ﹪,且其產生的劑量分布符合美國FDA之劑量品質的建議值。CVD鑽石薄膜雖有易受紫外線干擾、不確定度在5%以下。但只要仔細的針對CVD鑽石薄膜的特性進行分析與校正後,對於建立加馬血品照射儀的高輻射劑量分布的品質保證措施,CVD鑽石薄膜是很適當的量測工具。經由本文建立的方法,不僅可精確得到血品中心點的吸收劑量,亦可同時確認血品中任一點接受到的吸收劑量。
Graft-versus-Host Disease ( GVHD ) is a well-know complication of allogeneic bone marrow transplantation and is increasingly being recognized after solid-organ transplantation and transfusion.The radiation dose currently accepted to prevent GVHD is typically 15 Gy to 50 Gy. Blood irradiators are now in widespread use in the blood irradiation rather than LINACs because their security and convenient. Therefore, evaluated the dosimetry of blood irradiator is very important to confirm the safty of patients.
Many research workers have investigated the glow curve and dynamic of CVD diamond film fabricated with chemical vapour deposition methods ( CVD method ). This work is to study CVD diamond as a tool for blood irradiator dosimetry. We were measured the absorption dose distribution and spacial dose distribution of sample container of blood irradiator (Gamma- cell).
Results of experiment show that the response of absolute dose was display linearity(R-square 0.9853)for CVD diamond in high dose region ( 5-30 Gy),and measurement uncertainty is about 5%. The average absorbed dose is about 27.9± 5.46 Gy and the center absorbed dose is about 26 Gy of sample container of the blood-irradiator.The CVD diamond is a practical material for blood-irradiator measurements.
1. 甘龍(William F. Ganong),白禮源譯,《甘龍醫用生理學,下冊》(Review of Medical Physiology),台北:藝軒圖書出版社,1991/1992。
2. 許彬杰,翁寶山,《實用固體熱發光劑量測定術》,頁18-45,臺北:合記圖書出版社,2002。
3. 劉棋章,〈奈米尺度探討光子引發磊晶鑽石膜熱發光之微觀特性〉,清華大學原科所,博士論文,2003。
4. 陳俊良,〈氣相沉積鑽石晶片應用於高能輻射劑量之量測〉,清華大學原科所,碩士論文,2004。
5. Anderson, K.C., Goodnough, L.T., Sayers, M., “Variation in Blood Comp- onent Irriadiation Practice: Implications for Prevention of Transfusion -Associated Graft-versus-Host Disease, ” Blood, Vol. 10, 1991, pp. 2096-2102.
6. Andrew, J.T., A.S., R.T.T., Jane, C., C.M.D., Ed, M., “TLD Linearity VS. Beam Energy and Modality,” Med. Dosim., Vol. 27, 2002, pp.295-296.
7. Asai, T., Inaba, S., Ohto, H., Suzuki, K., Takahashi, K., Tadokoro, K., Minami, T., “Guidelines for Irradiation of Blood and Blood Components to Prevent Post-Transfusion Graft-vs.-Host disease in Japan, ”Transfusion Medicine, Vol. 10, 2000, pp. 315-320.
8. Benabdesselam, M., Iacconi, P., Briand, D., Lapraz, D., Butler, J.E., “Selected Themoluminescent Properties in CVD Diamond Film,” Radiat. Prot. Dosim., 1999, Vol. 84(1-4), pp. 257-260.
9. Bongner, L., Hartl, P., Scherer, J., Treutwein, M., Herbst, M., “Dosimetry of A Blood Irradiator,” Strahlenther Onkol., Vol. 174(8), 1998, pp. 431-436.
10. Brian, T.I., Moscovitch, M., “Light-induced TL and light-induced fading in Alpha -Al2O3:C, ” Radiat. Meas., 1996, Vol. 26(2), pp. 259-264.
11. Briand, D., Iacconi, P., Benabdesselam, M., Lapraz, D., May, P.W., Rego, C.A., “Thermally Stimulated Properties of CVD Diamond Films,” Diamond and Related Meterial, Vol 9, 2000, pp. 1245-1248.
12. Butson, M.J., Yu, P.K.N., Cheung, T., Carolan, M.G., Quach, K.Y., Arnold, A., Metcalfe, P.E., “Dosimetry of Blood Irradiation with Radiochromic Film,” Transfusion Med., Vol. 9, 1999, pp. 205-208.
13. Butson, M.J., Cheung, T., Yu, P.K.N., Stokes, M.J., “Blood Irradiation with Accelerator Produce Electron Beams, ”Biol. Med. Phys., Vol. 45, 2000, pp. 139-142.
14. Cuttone, G., Azario6, L., Barone Tonghi, L., Borchi E., Boscarino, D., “The Candido Project: Development of a CVD Diamond Dosimeter for Applications in Radiotherapy, ” Nucl. Phys. B(Proc. Suppl.), Vol 78, 1999, pp. 587-591.
15. Furetta, C., Kitis, G., Brambile, A., Jany, C., Gergonzo, P., Foulon, F., “ Thermoluminescencs Characteristic of a New Production of Chemic- al Vapour Deposition Diamond, ” Radiat. Protect. Dosim., Vol 84(1-4), 1999, pp. 201-205.
16. Furetta, C., Kitis, G., Kuo, C.H., “Kinetics Parameters of CVD Diamond by Computerized Glow-Curve Deconvolution (CGCD), Nucl. Instr. Meth., B160, 2000, pp. 65-72.
17. Hansen, E., Knuechel, R., Altmppen, J., Taeger, K., “ Blood Irradiation for Intraoperative Autotransfusion in Cancer Surgery: Demonstration of
Elimination of Contaminating Tumor Cells, ” Transfusion., Vol.39. 1998, pp. 608-615.
18. Horowitz, Y.S., Satinger, D., Oster, L., Issa, N., Brandan, M.E., Avila, O., Rodriguez-Villafuerte, M., Gamboa-deBuen, I., Buenfil, A.E., Ruiz- Trejo, C., “The Extend Track Interaction Model: Superlinearity and Saturation He-ion TL Fluence Response in Sensitized TLD-100, ” Radiat. Meas., 2001, Vol. 33, pp.459-473.
19. International Commission on Radiological Protection,“ Conversion Coefficients for use in Radiological Protection against External Radiation, ” ICRP Publication 74, Pergamon Press, Oxford, U.K., 1996.
20. Kretschmer, V., Blauhut, B., “ Blood, Blood Products and Blood Saving
Techniques, ” Bailliere’s Clinical Anaesthesiology., Vol.11, 1997, pp.
336-350.
21. Masterson, M.E., Febo, R., “ Transfusion Blood Irradiation: Clinical Ration- ale and Dosimetry Considerations, ” Med. Phys., Vol. 19(3). 1992.
22. Mckeever, S.W.S., Moscovitch, M., Townsend, P.D., “Thermolumines- cence Dosimetry Materials: Properties and Users, ” Nucl. Tech. Publ., 1995.
23. Pelszynski, M.M., Moroff, G., Luban, N.L.C., Taylor, B.J., Quinones, R.R., “Effect of γIrradiation of Red Blood Cell Units on T-Cell Inactivation as Assessed by Limiting Dilution Analysis: Implications for Preventing Transfusion-Associated Graft-Versus-Host Disease,” Blood, Vol. 83(6), 1994, pp. 1683-1689.
24. Ramesh, A.S., Frank, G.H., Nancy, L.D., Jeffrey, S.D., Elise, J.K., Kenneth, “C.A.Graft-versus-Host Disease Associate with Transfusion of Blood from Unrelated HLA- Homozygous Donors, ” the New England Jour. of Med., Vol. 328, 1993, pp. 766-770.
25. Stepheanie,J.Lee, “New Approaches for Preventing and Treating Chronic Graft-versus-Host Disease,” Blood, 2005, Vol. 105(11), pp. 4200-4206.
26. Vittone, E., Manfredotti, C., Fizzotti, F., Lo, A.g., Polesello, P., Ralch- enko, V., “Themoluminescence in CVD Diamond Films: Application to radiation dosimetry, ” Diamond and Related Materials, Vol. 8, 1999, pp. 1234-1239.