氫氧基磷灰石(HA)因具有良好生物相容性、無細胞毒性，並且為人體中骨骼的主要成分，目前已被廣泛研究與使用在骨填充材料上。而β型式三鈣磷酸鹽(β-TCP)因植入生物體中能釋放出大量鈣、磷離子，有助於新骨的生長，亦為常用之磷酸鹽陶瓷，故將HA與β-TCP相互搭配使用，形成雙相磷酸鈣材料，更有利於骨缺損修補。本研究主要以單相的HA添加適當發泡劑，經由一次煆燒後得到雙相的HA與β-TCP多孔雙相磷酸鈣骨填充材料。
本研究所使用的發泡劑以蔗糖(Sucrose)為主，HA : Sucrose = 1 : 0.75(重量比)，壓錠後，升溫至1000 ℃，持溫30分鐘後以爐冷方式降溫，便可得到多孔雙相磷酸鈣骨填充材料。在升溫過程中，蔗糖發泡完後便分解且揮發至空氣中，所得到之孔洞包含大孔(macro-pore)與小孔(micro-pore)，大孔孔徑為100~150 μm，而小孔孔徑為0~50 μm。HA含量可在60 wt%以上，孔隙率可達70%，抗壓強度為0.2~0.6 MPa。這些性質可依HA與蔗糖比例，煆燒條件等而調整。材料無明顯細胞毒性也不會對生物體造成慢性發炎反應。

Hydroxyapatite(HA) has been wildly studied and used in bony implant, because HA has the advantages, such as free of cell toxicity, excellent bio-compatibility, and it is the major component of human bone. Beta-tricalcium phosphate(β-TCP) is also popular in implantation usage, due to its ability to release abundant calcium and phosphate ions that will provoke the bony growth. In this study, I aimed to prepare porous biphasic calcium phosphate materials as bony implant. We used a single phase HA and a foaming agent to form a porous biphasic(HA and β-TCP) material after one step calcination.
The major foaming agent used is sucrose. HA and sucrose with the ratio 1 to 0.75 was found optimal. After being calcined at 1000℃ for 30min, a porous and biphasic material was obtained. The sucrose decomposed and evaporated during the process. The material has micro- and macro-pores, and the pore size ranges from 0~50 μm and 100~150 μm, respectively. The porosity was higher than 70%, HA could be higher than 60wt%, and the compressive strength was about 0.2~0.6 MPa. All these parameters could be adjustable by HA/sucrose ratio and calcination parameters. The synthesized material was free of cell toxicity, and there was no long-term inflammation in situ.

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