N/A

Abstract
Animal lifespan and physiology can be largely modulated by living environments. Research in Drosophila melanogaster, an ideal model organism for aging study, has shown that longevity can be regulated by a variety of environmental factors such as temperature or diet components. However, the influence of complicated social environments has been just begun to be explored. In this thesis, we cohoused target flies with different strains or species and found that exposure to different social donors could lead to either beneficial or deleterious influence on fly lifespan and stress resistance. Animals living with long-lived partners tended to have longer lifespan, while animals living with short-lived partners tended to have shorter lifespan. Moreover, our findings suggest that this social modulation of lifespan is not dependent on physical contact and unlikely due to microorganisms. Last, cohousing with different social donors also modulated targets’ stress resistance, although the direction of change is not consistent with the change in lifespan. Together, our study provides a new evidence that different social partners could have pronounced impacts on fly physiology and longevity.

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