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研究生: 張耘菁
Yun-Ching Chang
論文名稱: Expression Drosophila ter94 mutants recapitulate a hereditary multi-system disorder IBMPFD
IBMPFD果蠅模式之建立
指導教授: 桑自剛
Tzu-Kang Sang
口試委員:
學位類別: 碩士
Master
系所名稱: 生命科學暨醫學院 - 生物科技研究所
Biotechnology
論文出版年: 2008
畢業學年度: 96
語文別: 英文
論文頁數: 49
中文關鍵詞: 多重器官退化性疾病
外文關鍵詞: IBMPFD, VCP, ter94
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  • Abstract ii 中文摘要 iv Acknowledgement v Introduction 1 Materials and Methods 5 Results 9 Drosophila ter94 is essential for cell survival 9 RNA inhibition of Drosophila ter94 affects eye development 11 Overexpression of ter94 mutants that correspond to IBMPFD alleles cause eye degeneration 11 Expressing mutant ter94 in muscle cells disrupt normal pattern of musculature and affect heart development 13 Expressing mutant ter94 in muscle cells cause defect in flight performance 15 Overexpression of ter94R188Q in nervous system leads to brain defect 16 The relationship of ter94 and cofactors 16 Discussion 18 Figures 22 Reference 45

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