摘要

樹枝狀分子大約在1984年由D. A. Tomalia等人所發現的一種新型的聚合物，它具有單一分子量分佈(monodispersity)、具多孔性的內部、高溶解度、低黏度及結構設計多樣化等優點，這對於醫藥、生物科技、光學等領域而言都有很大的潛力，因此近幾年來很受到科學家的重視。

本篇論文的研究重點在於將樹枝狀分子長在矽基材上後，探討樹枝狀分子半數代和整數代的穩定性：溫度對表面能變化的影響；並佐以熱脫附常壓游離質譜儀來佐證論點。之後在把樹枝狀分子應用到電極式生物感測器元件上，將金奈米粒子以自組裝方式固著於電極間隙，進行電性量測，此方式可提供吾人一簡單、快速且低成本的應用領域。

Abstract
The poly(amidoamine) dendrimer is a new type polymer which discovered by D. A. Tomalia et al. in 1984. The dendrimer has attracted scientist’s attention for the recent years. It possesses some important advantages, like monodispersity, porosity, high aqueous resolution, low viscosity, variety of structure design, and has a number of potential applications for medical science, biotechnology and optics science yet.

The key points of investigation are to study the chemical change of dendrimer under thermal condition to obtain the surface energy change；we use Thermal Desorption-Atmospheric Pressure Ionization Mass-spectroscopy to support reason. The poly(amidoamine) dendrimer self-assembling on a silicon wafer between nano-gap gold electrodes，then gold nanoparticles is established on the surface between electrodes.This method provide us a simple、fast and cheaper way.

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