傳統在討論基因表現量的變化是如何受DNA序列變異的影響的議題時, 常使用的方式為看個別基因的表現量的變化, 但在後來的研究中發現, 許多相同功能性的基因表現量必須一起被探討是如何受DNA序列變異的影響. 單看其中的一個基因表現量與序列變異的關連性似乎並不穩定, 一旦更換資料則連結變動很大. 因此在面對這個議題時, 我們是使用基因模組整體的表現量來做探討. 我們考慮三種不同建立基因模組的方法, 分別是優先選取內部基因的基因模組, 優先選用外部基因的基因模組, 同時考慮內部基因以及外部基因的基因模組. 觀察不同結構的基因模組的基因表現量跟DNA序列變異的關係. 最後, 我們會在兩筆不同的癌症資料上, 觀察同一個基因模組所找出來的DNA序列變異是否具有一致性. 最後發現在我們的三種基因模組下DNA序列變異的關連性依然沒有出現較好的一致性, 這與文獻上的猜測相悖.

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