廣泛使用的細胞分裂紡錘體抑制劑─秋水仙胺，於先前研究中顯示，在中國倉鼠卵巢細胞內具有加重紫外線所引起細胞死亡的效應。本研究主要探討秋水仙胺對於基因修復的影響。研究中係利用一敏感的基因損傷針測技術－彗星測量法 (comet assay) 為主軸，去探究秋水仙胺對於細胞ＤＮＡ的影響性，其結果如下所示：首先，在照射過紫外線的細胞被處以秋水仙胺的實驗中顯示，秋水仙胺對於ＤＮＡ修復過程中有累積ＤＮＡ鏈斷的效應，此效應並非來自於秋水仙胺本身對ＤＮＡ鏈鎖的影響；再者，這樣的效應亦非出自於細胞凋亡的引發。進一步的實驗顯示，即使細胞在不同的細胞週期中，秋水仙胺仍然可顯示此效應；然而，在施以相同的處理對核苷酸切除修復機制缺陷的細胞 (Nucleotide excision repair-deficient cells)，秋水仙胺便無法顯示其影響；故表示秋水仙胺的效應跟核苷酸切除修復機制有關。於更進一步的機制探討中顯示，秋水仙胺抑制了ＤＮＡ修復過程中的鏈鎖連黏步驟，造成細胞進行核苷酸切除之後無法執行正常的ＤＮＡ接連功能，因此，這可能即為秋水仙胺在中國倉鼠卵巢細胞內具有加重紫外線所引起細胞死亡效應的原因。此一特殊抑制基因修復的分子機制尚待釐清。

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