精實六標準差 (Lean Six Sigma)乃結合精實(Lean)原理與六標準差(Six Sigma)手法，兼具加快流程速度與系統性統計分析的優點，是當前企業之熱門流程管理手法。此外，在不容許任何誤差與缺失，以病人安全為根本的醫療產業，其與六標準差強調顧客滿意與近乎完美的理念，可說是不謀而合；而精實著重消除浪費與改進速度，更是為競爭激烈的醫療產業注入新的思維。但，醫療的不確定性與資訊的不對等，讓醫療品質的議題引起許多紛爭，且醫療流程產生不良品的代價為病患之健康，是難以量化評估及彌補。如何應用精實六標準差進行以病患為中心的流程改善，是一重要的研究方向。
本研究應用精實六標準差改善程序改善急性心肌梗塞就醫流程。依循六標準差的DMAIC步驟，找出關鍵品質特性，藉由價值溪流圖之繪製，找出流程中非加值活動，並運用特性要因圖進行真因分析，以腦力激盪產出改善方案，剔除浪費提升流程週期效益。改善後的D2B流程，其流程時間不僅小於ACC/AHA訂定之標準(90分鐘)，更減少了58.4%的流程時間。流程週期效率由32.27%提升至51.81%，平均住院天數縮短3天，節省醫療資源耗用468.6萬/年。本研究顯示精實六標準差除可提升醫院的醫療品質，更可強化其市場競爭力。

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