本論文研究使用原盤狀微胞作為模板成長有序矽酸鹽中孔洞奈米材料。實驗以長鏈磷脂分子DPPC及短鏈的DiC7PC 以三比一的比例混合於水溶液中形成直徑約20 nm圓盤型微胞，並添加帶正電的DC-Chol或帶負電的DPPG形成帶電微胞。在含圓盤型微胞的水溶液中加入四甲氧基矽烷(TMOS)，使其沈積在微胞表面，形成有機-無機複合中孔洞結構材料。研究結果發現主要會形成由圓盤型微胞堆疊成長條的結構，亦會有多層層狀結構共存；在特定狀況下，例如帶有10%以上之正電荷圓盤型微胞，並不會堆疊，只會形成包覆單一盤狀分散的粒子，因單一的矽酸鹽分子解離的負電荷都全吸附在單一的正電荷圓盤型微胞模板上，此矽酸鹽分子就被中性化，不再有剩餘的負電荷連接到其它圓盤狀微胞上，故不會造成圓盤型微胞堆疊，僅形成單一圓盤狀結構；若亦加入NH4F促進TMOS解離，則可以形成良好的長條堆疊的結構，因此時高度解離的矽酸鹽分子上的負電荷可以將帶正電荷圓盤型微胞連結。若使用負電荷圓盤型微胞，在5% DPPG 時，會形成圓盤型橫向連接數個及縱向連續堆疊的長條結構。在10%及30% DPPG 時，只會形成圓盤縱向連續堆疊的寬度約咯整齊的長條結構。但在15% DPPG時則會形成不太規則間距略大的堆疊結構及少量間距較大的堆疊結構，若加入NH4F則會形成寬度不整齊的長條形堆疊。當DPPG的含量增加到30%時，可藉由DPPG解離的鈉離子形成較穩定的橋接，而形成的長條堆疊結構。pH值亦會影響矽酸鹽的地積自組裝結構，在水溶液為pH 2時，對DPPC圓盤微胞、含15% DPPG的圓盤微胞及含15% DC-Chol的圓盤微胞模板，都會形成多條聚集成的長條堆疊結構，圓盤微胞模板除了平板面相連接，側邊也會連接，因此會形成徑向由數個圓盤微胞組成，縱向由圓盤堆疊成長條。但15% DPPG的圓盤微胞模板，pH2時所形成的多條聚集成的長條形堆疊結構寬度較不整齊，15% DC-Chol及DPPC的圓盤微胞模板則形成寬度較齊一的多條聚集成的長條堆疊結構。pH高於2時，對含15% DPPG的圓盤微胞模板，圓盤微胞模板則大都堆疊成不規則獨立或相連團塊。對中性的圓盤微胞模板，在pH 3時會形成寬度較齊一的單一長條堆疊結構，隨pH值上升，多層層狀結構增多，而單一長條堆疊結構變少。在較高的酸性情況下，如pH2，矽酸鹽有較慢的解離及縮合速率，使矽酸鹽有沈積及新解離的到達，使圓盤微胞模板除了平板面連接，側邊也會連接，因此會形成多條聚集成的長條堆疊結構，以及會出現由圓盤以垂直於圓盤面方式用側邊連接而呈現橢圓孔。另外也研究將前驅物硝酸銀(AgNO3)浸泡於合成好之中孔洞材料水溶液中，待銀離子吸附於表面後再添加還原劑NaBH4還原為銀離子，實驗結果顯示銀離子可吸附在表面並還原，亦可使原本結構為單盤狀之正電荷模板系統轉化為長條狀結構。

Small-Angle X-ray scattering (SAXS) and TEM were used to investigate the structural properties of mesoporous silica materials prepared by condensation of tetramethyl orthosilicate on the zwitterionic bicelle, cationic bicelle, anionic bicelle and cationic bicelle-DNA complex. Using zwitterionic bicelles (mixing DPPC and diC7PC at a ratio of 3:1), thread-like structure formed by one-dimensionally stacked discs ( Å-1) as well as lamellar structure ( Å-1) would be formed in coexistence. The lamellar structure was formed with fused bicelles that have a thinner bilayer thickness. With the doping of cationic lipids above about 10%, only isolated discs were formed with a coating of silicate layer. The hydrolyzed TMOS molecules are adsorbed to single cationic bicelle due to the strong attraction of the positive charges on the cationic bicelle surface. However, with the presence of NH4F which could accelerate the hydrolysis of TMOS, thread-like structure was formed by stacking discs into long thread. With the doping of 5% DPPG, which is a negatively charged lipid, bundles of stacking disc threads were formed. With 10 % and 30% DPPG, isolated threads were formed by stacking discs. However, with 15% DPPG, irregular stacking of the discs would be formed with different d-spacings ( and 0.107 Å-1). At low pH, such as pH 2, both the hydrolysis rate and condensation rate of TMOS becomes much lower, other than stacking on the disc face, the discs are also connected side-by-side to form bundles of long structure. Increasing the pH higher than 2, the side-to-side disc connection are significantly reduced.

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