細胞增生核蛋白已知為去氧核糖核酸合成過程中的重要因子，同時也被證實參與在核苷酸切除修復和鹼基切除修復之去氧核糖核酸修復機制中。我們先前研究發現核苷酸切除修復和鹼基切除修復同時發生時，鹼基切除修復強勢過於核苷酸切除修復，並造成核苷酸切除修復延遲。進一步，我們分析增生細胞核蛋白多寡如何影響鹼基切除修復。由結果指出，血清缺乏狀況的細胞於過氧化氫引起的去氧核糖核酸氧化損傷中，將使延鹼基切除修復過程延長，而核苷酸切除修復卻不受其影響。相同地，移除細胞增生核蛋白的細胞也具有延遲鹼基切除修復作用的效果，反之，若過量表現細胞增生核蛋白有助於弭除血清缺乏狀況的鹼基切除修復延遲。此外，同時過量表現細胞增生核蛋白及抑制去氧核糖核酸複製，將癱瘓鹼基切除修復作用而無法消除氧化損傷。此研究證實，細胞增生核蛋白具有在去氧核糖核酸複製機制中，共同參與鹼基切除氧化傷害修復的重要角色。

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