在此次的研究中，我們發展了一種新型的光學外差式偏光儀，以用來量測對掌性物質溶液的濃度。而為了要減少量測中的環境對訊號所產生的干擾，TE和TM光波的共光程干涉技術被運用在我們的系統架構中，並且擺放一個相位可調式波片在樣品後面，利用它去增強樣品造成偏振態旋轉所引起的相位訊號，而當相位可調式波片的相位延遲量接近180度時，這個增強的能力可以超過100倍。在實驗中，利用我們所發展出來新的靈敏度增強型之偏光儀去進行葡萄糖溶液旋光量測，當調整相位可調式波片的相位延遲量為177.307度，且考慮相位可調式波片快軸軸向的誤差時，其角度放大倍率範圍為-57.853 ~ -60.091，經過計算得到的角度解析能力範圍為6.16×10-4 ~ 6.40×10-4度，其對應的濃度解析能力範圍為13.48 ~ 14.00 mg/dl。我們預期系統在經過改善後，此新型的偏光儀未來將可被運用於糖尿病患非侵入式的血糖濃度監測。

A novel heterodyne polarimeter is designed to measure the concentration of chiral media. Optical common-path for the interference of the TE and TM waves, after a polarizer, is set up in our system to reduce noises from the environment. A phase-variable waveplate is placed behind the sample to enhance the phase signal change of rotation of polarization introduced by the sample itself. This enhancement can be excess two orders in amplitude when the retardation of the phase-variable plate is set close to 180 degree. With this polarimeter, the enhancement is -57.853 ~ -60.091 when the phase retardation of the phase-variable waveplate is 177.307 degree and considering the error of orientation angle. After calculating, the measurement of optical rotation angle of glucose solution with high resolution of 6.16×10-4 ~ 6.40×10-4 degree experimentally can be achieved, corresponding to concentration resolution of 13.48 ~ 14.00 mg/dl. We expect that, by further improvement, it can be applied in noninvasive blood glucose concentration monitoring for diabetics in the future.

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