核磁共振造影技術，為非侵入性影像學檢查是近年來醫學界的重大發明，而具有超順磁特性鐵氧化物為基礎的奈米粒子，例如四氧化三鐵，更是已被廣泛地用於信號增強之對比顯影劑。
本論文成功地藉由化學還原法合成出粒徑均勻之超順磁性四氧化三鐵奈米粒子，並且利用相轉換的程序使奈米粒子從油溶性轉為水溶性。同時探討在油包水微乳液系統中，水的含量對於前驅物正矽酸乙酯(TEOS)轉變為二氧化矽殼層的影響，同時比較不同其顯影能力及飽和磁化量的變化。
最後，利用動態光散射及核磁共振儀量測水溶性四氧化三鐵奈米粒子之水合粒徑及遲緩率，並與具有相同粒徑的臨床顯影劑比較，顯示其有更好遲緩率表現。

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