本論文的內容在於探討樟腦磺醯胺衍生物之掌性1,3-二□環戊-4-酮化合物14對於不對稱串聯反應之研究，利用1,3-二□環戊-4-酮化合物14先與巴豆酸甲酯行Michael反應，先建立兩個連續的掌性中心，再接著做α-取代反應來得到第三個連續的掌性中心，其前兩個掌性中心的建立可以達到大於98%非鏡像選擇性及82%以上的產率，第三個掌性中心則可以有80.4/1.8到大於99/1的非鏡像選擇性；1,3-二□環戊-4-酮化合物14亦可與雙取代的α-巴豆酸甲酯反應，同時搭配掌性化合物33提供質子可得到大於98%非鏡像選擇性與64%產率。

This thesis reports the asymmetric tandem reaction using 1,3-dioxolan-4-one 14. At first, Michael reaction of the enolate from 1,3-dioxolan-4-one 14 with methyl crotonate afforded product 20b with two contiguous chiral centers. Compound 20b underwent α-substitution reaction and generated the third chiral center. The first Michael reaction gave a single product in 82% yield, and the second reaction afforded product with high diastereoselectivity(up to 80.4/1.8) in 53-83% yield. Enolate of 1,3-dioxolan-4-one 14 reacted with methyl tiglate and, after the treatment with chiral compound 33 as proton source, afforded single product 31 in 64% yield.

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