基因是一切生命現象的基礎，生物要表現某項功能，一定要具有此功能的基因被啟動，因此要了解生命的本質必須由了解基因的功能著手。cDNA微陣列(cDNA Microarray)實驗可以同時檢測大量基因，降低了研究基因的障礙。
進行微陣列實驗的目的之一，是希望能偵測出不同的種類其基因表現的差異。為了要正確的比較基因表現量的差異，必須將實驗數據先進行歸一化。再使用微陣列顯著性檢定，檢視那些基因的表現量是有差異。本論文主要探討cDNA微陣列實驗中基因表現量對數比變異度之估計，以及如何利用此估計量改進微陣列顯著性檢定的檢定力。

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