本文以數值流力與實驗觀測探討生物晶片的微混合器設計，針對微混合器系統的微幫浦與主流道兩個次元件探討，分別設計產生混合的方法。微幫浦設計上採用主動式脈衝驅動流體達到混合，在兩個流道入口以相位差180o造成兩股流體之間的最大動量差，並且以週期性的交錯來提升兩股流體的混合效率。在主流道的設計上採用被動式蜿蜒形結構增強法，放置交錯排列的十個擋體於主流道的兩側，使得主流道有擴張與收縮的效應來增強混合效率。數值的計算部份，則以SIMPLEC模式法求解，針對兩個不同的混合增強方式設計不同的邊界條件與初始條件，並分析流線場與濃度場。脈衝流混合增強法的研究參數為雷諾數Re與史卓荷數St，蜿蜒形結構混合增強法的研究參數為雷諾數Re與流道擴張收縮比A／R。研究結果顯示脈衝流在低雷諾數會產生動量不足，太高的雷諾數會使得流體混合時間太短。史卓荷數在St＝12.6可得到較好的混合結果。在被動式蜿蜒形結構的分析上顯示，當流道的擴張與收縮比A／R＝0.25可增加微混合器的使用範圍，兩股流體的介面因為拉長，使得流體的混合在較低的雷諾數Re＝3仍然由擴散來主導，在較高的雷諾數Re＝30，則藉由迴流區的增長使得對流的效應主導混合。在A／R＝0.25∼0.5的範圍，流體的混合效果隨著雷諾數變大而增加，在A／R＝0.75∼1的範圍，流體的混合效果隨著雷諾數變大而減低。

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