在生物科學的領域當中，探討細胞間的交互作用在生理機制的影響是一個很重要課題，也由於在生理系統上含有各種不同的細胞，不同種細胞的特徵與表現甚至是同種細胞間都不會完全相同，若給予外在的刺激，所釋放的訊號也會有所不同。為了要微觀的得取真實細胞的情況，現今已有各種探討單細胞間釋放物質的研究，而對於分析這些單細胞彼此間化學物質的傳遞也有許多種量測方式，但常見的困難點在於包含要先將複雜的樣本作預處理、濃縮，花時間且繁複，並由於單細胞經過刺激後在極短的時間內即會釋出化學分子，所以需要即時做好存取，並即時偵測，所以我們需要選擇一個整合性的平台，將各部分的工作有效率且有系統的結合在一個晶片上，以其能達到即時觀測這些化學分子隨著時間的變化。

此研究提出具兩大特色的微流道晶片，能調控電場自由選擇不同帶電性的樣本，並且能時序控制濃縮待測分子，將偵測極限降低，且不再需要再進行酵素或化學分子修飾，就能進行濃縮反應。本研究製作了一整合性的微系統平台，能夠將所有系統整合，期望能在每份樣本連續進入流道內時能夠及時做好濃縮，並且也能順序的做電化學訊號的偵測。濃縮效果是透過在奈米線區域給予電場加以極化，各奈米線間形成電雙層的帶電柵欄，將顆粒較大以及帶有相同電荷的分子濃縮在奈米線區域前，利用神經傳導物質具有特殊帶電性質，能作高效率的時序濃縮，透過濃縮將每段時間的訊號保存並放大，並將各時間收集的待測分子引領到電化學訊號之偵測區域，希望能觀察神經細胞的分泌物質隨著時間變化的結果，同時也能保有偵測極限低的特質。

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