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研究生： 馬鈺婷
Ma, Yu-Ting
論文名稱： 動物核醫診斷與治療之工作人員劑量及動物外釋標準研究
Research on Staff Dose and Animal Release Standard of Veterinary Nuclear Medicine
指導教授： 許芳裕
Hsu, Fang-Yuh
許靖涵
Hsu, Ching-Han
口試委員: 趙自強
游澄清
學位類別： 碩士
Master
系所名稱： 原子科學院 - 生醫工程與環境科學系
Department of Biomedical Engineering and Environmental Sciences
論文出版年： 2020
畢業學年度： 108
語文別： 中文
論文頁數： 130
中文關鍵詞： 核子醫學診斷 、核子醫學治療 、獸醫 、劑量限值 、放射性藥物
外文關鍵詞： veterinary medicine, Microshield, dose limitation, animals releasing
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    • 當今社會隨著醫療的蓬勃發展，促進人類壽命逐漸延長，並享有更高之生活品質，而於獸醫醫學方面，同樣有很大的突破，在寵物之疾病治療與診斷上，可以提供更有品質之醫療技術，並且有鑒於現代人們願意投入更多的時間與金錢在寵物上，因此也大幅增加人們重視獸醫醫學。
    動物醫學在核子醫學方面有很大之進展，可以早期診斷動物之疾病並早期治療，但對於利用放射性藥物對動物進行診療，可能會對工作人員與飼主產生輻射安全的疑慮，因此本研究利用程式MicroShield進行模擬，利用三種於臨床上最常使用之藥物，並依照其個別之診療方式，保守估計並模擬獸醫院之工作人員可能接收到之年劑量，與動物在進行診療作業後，體內會有殘存劑量，其可外釋之時間，以及飼主及家中成員在照顧寵物時，所會接收到之劑量，是否會對人體產生輻射安全之危害。在國內尚未有明確之法規進行規範，因此本篇研究利用保守評估劑量之方法，對於動物外釋之時間與動物返家後，飼主之照顧注意事項及輻射安全提出建議。

    With the vigorous development of medical treatment in today’s society, human life is gradually extended and higher quality of life is enjoyed. As for veterinary medicine also has a great breakthrough, it can provide more quality techniques in the medical diagnosis and treatment of pet diseases. In view of people are willing to spend more time and money on pets, it has also greatly increased the importance of veterinary medicine.
    Veterinary medicine has made great progress in nuclear medicine. It can diagnose animal diseases and treat them early. However, with radioactive drugs in nuclear medicine may cause radiation safety concerns to staff and owners. Therefore, this study used the MicroShield software program to simulate three kinds of radioactive drugs in clinical practice, with different methods of diagnosis and treatment introduced in international literature, and conservatively estimated and simulated the doses that may be received by the staff of the veterinary hospital. When the pets can be released after the pets finish the diagnosis or treatment, the dose that the owner and family members will receive when they take care of their pets after the release were discussed in this study. In addition, this study also summarizes the international literature reports, and gives suggestions on the time for the animal to be released from the domestic veterinary hospital and the animals’ care and radiation safety after the animal returns home. In view of the fact that there is currently no clear standard for radiation safety in animal nuclear medicine clinics in Taiwan, the results of this study can provide a reference for the relevant radiation protection control of the competent authority in the future.

    中文摘要 I ABSTRACT II 誌謝 IV 目次 V 圖目錄 VIII 表目錄 IX 第一章 緒論 1 1.1 前言 1 1.2 動物醫院之核醫診斷技術 2 1.2.1 核醫診斷之儀器 2 1.2.2 核醫診斷藥物Tc-99m 7 1.2.3 核醫診斷藥物F-18 10 1.3 動物醫院之核醫治療技術 13 1.3.1 核醫治療藥物I-131 13 1.4 文獻回顧 15 1.4.1 飼主與醫院工作人員之劑量 15 1.4.2 動物外釋標準 16 1.5 研究目的 17 第二章 材料與方法 18 2.1 程式MicroShield模擬照影劑量 18 2.1.1 MicroShield 19 2.1.2 假體選用 19 2.1.3 模擬劑量之數值意義 20 2.2研究方法分析與設計 22 2.2.1 使用Tc-99m檢查之程序與劑量 23 2.2.2 使用F-18檢查之程序與劑量 26 2.2.3 使用I-131檢查之程序與劑量 27 2.3 Tc-99m藥物之評估 28 2.3.1 相關工作人員劑量 29 2.3.2 動物外釋評估 34 2.4 F-18藥物之評估 38 2.4.1 相關工作人員劑量 39 2.4.2 動物外釋評估 42 2.5 I-131藥物之評估 45 2.5.1 相關工作人員劑量 45 2.5.2 動物外釋評估 47 2.6 國際相關文獻之輻防要求匯整 48 第三章 結果與討論 54 3.1 Tc-99m診斷之劑量 54 3.1.1 工作人員劑量 55 3.1.2 飼主劑量 71 3.2 F-18診斷之劑量 71 3.2.1 工作人員劑量 79 3.2.2 飼主劑量 89 3.3 I-131治療之劑量 94 3.3.1 工作人員劑量 95 3.3.2 飼主劑量 103 3.4 動物核醫之輻射防護建議 105 3.4.1國際相關輻防措施彙整 106 3.4.2國內核醫診療作業之輻防建議 112 第四章 結論 114 參考文獻 116 附錄一 工作人員於藥物注射作業接收之劑量 119 附錄二 工作人員於擺位作業接收之劑量 121 附錄三 工作人員於動物移至作業接收之劑量 123 附錄四 工作人員照顧留置動物作業接收之劑量 125 附錄五 飼主接收到之劑量 127 附錄六 動物外釋標準計算 130

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