研究生: |
張勁淳 Ching-Tsun Chang |
---|---|
論文名稱: |
利用奈米結構增加免標定干涉式光纖感測器之靈敏度 Sensitivity Enhancement of Fiber-Optic Interferometry Biosensor for Label-Free Detection |
指導教授: |
曾繁根
Fang-Gang Tseng |
口試委員: | |
學位類別: |
碩士 Master |
系所名稱: |
原子科學院 - 工程與系統科學系 Department of Engineering and System Science |
論文出版年: | 2008 |
畢業學年度: | 96 |
語文別: | 中文 |
論文頁數: | 84 |
中文關鍵詞: | 生物感測器 、免標定 、即時 、體內 、檢測極限 、奈米結構 、干涉術 |
外文關鍵詞: | Biosensor, Label-Free, Real-Time, In-Vivo, Detection Limit, Nano-Structure, Interferometry |
相關次數: | 點閱:2 下載:0 |
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一個能夠提供體內即時檢測的感測器不僅可以幫助疾病的檢測,還可以成為醫學和生物研究上一個強而有力的工具。法布里-珀羅干涉式光纖生物感測器在前人的研究中被證實是一個可以即時檢測的感測器,而且有潛力進行體內檢測。
發展中的法布里-珀羅干涉式光纖生物感測器具有相當程度的靈敏度,但是有鑑於醫學和生物研究中生物指標的微量性,以及某些特定研究中生物指標變化的快速性,靈敏度更高、反應更快速的感測器一直是各研究團隊一項重要的研究議題。
本論文利用奈米結構增加感測器的反應面積,成功的提高了感測器的靈敏度,並且在免疫球蛋白的檢測上將檢測極限向下改善了一個數量級,達到了1ng/mL的感測極限濃度。除此之外,奈米結構的使用使得原本需要透過標定奈米金球以進行三明治檢測法的感測器成為一個能夠進行免標定檢測的感測器
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