生物可分解性人工合成之高分子因具有生物可分解性、生物可相容性、無毒性之特點，適合在藥物投遞系統及組織工程上研究發展。其中，兩性團聯共聚高分子在水相中具有自組成高分子微胞的特性，在藥物釋放研究上進展相當迅速。
聚酸酐為用酸酐鍵結而成之高分子材料，具有上述生物可分解性人工合成之高分子的性質，且尤其表面降解的特性，做為藥物載體時具有良好、易控制釋放的優點而廣受到醫藥學界的重視；其中聚癸二酸酐(poly(sebacic acid), PSA)因其化學結構為簡單的八個碳氫(-CH2-)雙酸酐長碳鏈聚合體，在文獻中，是聚酸酐材料中最常研究、應用和其他材料鍵結的材料；聚乙二醇(poly(ethylene glycol), PEG)本身為一聚醚類高分子，具有高親水性、不易分解性和高生物相容性，和疏水性材料鍵結後會形成兩性團聯高分子，在水相中會自組裝成高分子微胞，增加nanoparticles在血液中的立體阻礙性，加強在人體中的循環時間，文獻中指出[1]，具有高分子量的PEG5000比PEG2000會有較佳的立體阻礙性，不易被巨噬細胞所吞噬。本實驗中，首先以具雙酸單體sebacic acid酸酐化後，跟poly(ethylene glycol) methyl ether(mPEG5000)進行熔融縮合反應，形成親疏水性二團聯共聚物mPEG-PSA，其分子量在12900左右。因為mPEG-PSA具有兩性特質，利用乳化法在水相中自組裝(self-assembly)成奈米尺寸高分子微胞，經冷凍乾燥後粒徑大小在185nm左右，而包覆疏水性抗癌藥物紫杉醇後，粒徑會加大到215nm，並以AFM觀察所製備的高分子微胞之形態。在降解方面，因聚酸酐對水及熱的不穩定性，而PES14又具有親水性mPEG易使水滲透至內部情形下，在pH=7.4溫度37℃的磷酸緩衝溶液環境，大約一天時間即降解完畢；在紫杉醇釋放方面，一開始的3小時內會快速釋到50%左右，之後直至第7天為止，會從50%慢慢釋放至80%左右。比較有無包覆紫杉醇的粒徑來看，包覆紫杉醇後會穩定內部核心使粒徑穩定度會比未包覆的好；但不論在何溫度，有無包覆紫杉醇情形下，從溶液外觀來看，高分子微胞不會有雲霧狀聚集產生，雖然實驗中在37℃及常溫下測得的粒徑會逐漸增加，但增加輻度不大(<500nm)，且一段時間後，高分子微胞水溶液會呈現透明澄清，推論，其粒徑變化應是PSA降解後，整個nanoparticles結構變化的結果。

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