近幾年來，微量元素與人體健康的關係日益受到人們的重視，對人體內的生化反應能產生重大的影響，並參與生物分子中的組成，具有特異性的功能。微量元素臨床醫學，已引起世界各國的研究熱潮，成為臨床醫學上的醫療指標。
為了協助國內微量元素臨床醫學的診斷，本研究分析人體中的微量元素，希望藉由微量分析化學的觀點，從樣品收集、污染控制及儀器測定上予以充分的考量，期能發展新的臨床醫療檢測技術，建立一套簡易、快速、可信度高之分析方法，以適用於人體尿液中微量元素的分析方法。
本研究使用多元素石墨爐原子吸收光譜儀(SIMMA 6000)，直接且同時測定尿液中的鉍, 鉛, 鎘, 硒, 和銻元素，由於尿液中蛋白質及無機鹽類將會對直接測量產生干擾，且此五種元素在尿液中的含量均低，因此將尿液添加極微量待測金屬鉍, 鉛, 鎘, 硒, 和銻元素，並加入適當的鈀修飾劑，尋找儀器的最佳化設定及最佳分析條件。分析過程中並加入氫氣，以避免鈀沈積顆粒的聚集，使鈀顆粒較小，分佈更均勻，提升鈀穩定分析物的能力，來增進原子化效率。本研究已可利用含0.5%HNO3的去離子水，成功地找尋出分析人體尿液中的鉍, 鉛, 鎘, 硒, 和銻元素的最佳化條件，並實際應用於人體真實尿液的分析。
未來可利用校正曲線法與標準添加法定量尿液中的五種元素，找尋出鉍, 鉛, 鎘, 硒, 和銻五種元素的偵測極限，進而應用在實際臨床醫學上。

In the recent years, the effect of trace element on human health attracted much of the attention. Such elements has strong influence in human body biochemical reactions, it participated in the bio-molecular formation with special effects. A clinical medicine studies on the trace elements was the focus of international research, and became a clinical treatment directions.
This study was aimed to upgrade the medical research in Taiwan, with in depth study of trace element on human body functions, from the point of views of analytical chemistry, sample collection, pollution control and instrumental identification to make evaluations. In order to develop a new clinical technique for simple, fast, highly reliable analytical procedure, we want to identify and analysis the trace elements in human urine.
This study applied Multi-Element, Graphite Furnace Atomic Absorption Spectrometer (SIMMA 6000), to determine directly and simultaneously the compositions of Bismuth, Cadmium, Lead, Selenium and Antimony in Urine. Due to the protein and non-organic salts could interference against direct measurements, and the five elements are only trace in amount in the urine, thus we added very limited amount of Bismuth, lead, cadmium, selenium and antimony into the urine sample, plus appropriate amount of palladium (Pd) modifier, to determine the best possible process and the optimal analyze conditions. During the analytical process, hydrogen was introduced to prevent palladium particle precipitation and forming large particles aggregate, to make palladium particle smaller with even distribution. To improve palladium’s ability for stable analysis, for improved atomized efficiency. This study already applied simple non-ionized water (with 0.5% HNO3), successfully identified the optimal conditions to analyze the trace elements of Bismuth, Cadmium, Lead, Selenium and Antimony in human urine, and the practical application of clinical human urine analysis.
In the future, it is possible to apply corrected curve technique and standardized modifier addition to analyze quantitatively the four elements in the human urine, to identify the test limits of Bismuth, Cadmium, Lead, Selenium and Antimony, in order for application in the practical clinical medicine.

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