雷射剝蝕技術常應用於固體樣品分析，雷射剝蝕結合感應耦合電漿質譜儀 (LA-ICP-MS)為一具有強而有力的分析技術。LA-ICP-MS 的優點包括：可以直接分析固體樣品、具有高靈敏度、樣品分析速度快、可進行微區分析和縱深分析。本研究將液體樣品預先與甲基藍 (Methylene blue) 混合，定體積的樣品滴於鐵氟龍濾紙上，並將其乾燥後，以LA-ICP-MS進行定量分析。本研究所提出之分析技術，可同時分析多種元素含量，且幾乎不需要額外的樣品前處理程序，因此，可避免因為形成揮發性物質而使待測物遺失，同時也降低污染導入的風險；此外，在五分鐘內，可以同時完成濾紙樣品上15個元素的分析。研究結果發現，在雷射波長213 nm 的狀態下，將雷射系統參數做以下的設定：100%雷射能量，2 mm 離焦距離(defocus distance)，20 Hz 重複速率(repetition rate) 和8秒停留時間(dwell time)，可以將乾掉的液滴樣品完全剝蝕。本研究利用外標法和標準添加法進行LA-ICP-MS定量分析的研究，研究結果顯示，可得到很好的精密度(RSD<10%)和高回收率(95-105 %)，另外檢量線線性的相關係數皆很高(0.9922-0.9998)，偵測極限可低至0.04-0.81 ng mL-1，因此本研究所提出之分析技術在未來可以應用於任何液體樣品的定量分析。本研究亦針對真實環境樣品進行採樣分析，包括瓶裝水、自來水、游泳池水、湖水和模擬廢水；實驗結果顯示，儘管是在高濃度的有機物和無機物的基質中，待測物的訊號並不太會受到影響。

Laser ablation is most frequently applied to the analysis of solid samples. A combination of laser ablation (LA) with inductively coupled plasma mass spectrometry (ICP-MS) is one of the most powerful analytical techniques. LA-ICP-MS is advantageous because of its direct solid sampling capability, high sensitivity, fast analysis, microanalysis, and depth profiling capabilities. In this study, dried microdroplets of sample, previously mixed with methylene blue matrix, were quantitatively ablated from a PTFE (polytetrafluoroethylene) filter. The developed method needed nearly no sample pre-treatment for determining elements, therefore, the losses due to the formation of volatile compounds and presence of contaminants could be negligible. In addition, up to fifteen elements on a single filter sample can be determined within 5 min. It was found that a 213 nm laser with 100% laser energy and 2 mm defocus distance, at 20 Hz repetition rate and 8 seconds dwell time can ablate the dried droplet samples appropriately. Both the external standard and standard addition were applied for quantification by LA-ICP-MS. A good precision (RSD<10 %) and high recovery (95-105 %) can be obtained in this research. The high correlation coefficients (0.9922-0.9998) and low detection limits (0.04-0.81 ng mL-1) for most elements of interest showed that this method would be useful for future quantification in any kind of liquid samples. The proposed method was applied to real environmental samples, such as bottled water, tap water, swimming pool water, lake water and simulated wastewater. The results indicate that both inorganic salts and organic matrics cause negligible effect on signals even in high concentration.

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