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| 研究生： |
江宸安 Chiang, Chen-An |
|---|---|
| 論文名稱： |
利用交叉共軛插烯化系統衍生之電子豐盈二烯發展新穎狄耳士-阿德爾環加成反應 A Novel Diels-Alder Cycloaddition Employing Electron-Rich Dienes Derived from Cross-Conjugated Vinylogous systems |
| 指導教授： |
俞鐘山
Yu, Chung-Shan 夏克山 Shia, Kak-Shan |
| 口試委員: |
李靜琪
Lee, Jinq-Chyi 林俊成 Lin, Chun-Cheng |
| 學位類別： |
碩士 Master |
| 系所名稱： |
原子科學院 - 生醫工程與環境科學系 Department of Biomedical Engineering and Environmental Sciences |
| 論文出版年： | 2020 |
| 畢業學年度： | 108 |
| 語文別： | 中文 |
| 論文頁數： | 136 |
| 中文關鍵詞： | 電子豐盈二烯 、狄耳士-阿德爾環加成反應 |
| 外文關鍵詞： | Diels-Alder Cycloaddition, Electron-Rich Dienes, Cross-Conjugated Vinylogous systems |
| 相關次數： | 點閱：2 下載：0 |
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本論文以醛基形式插烯化交叉共軛予體進行聯繼插烯化Michael / HWE反應時，意外發現醛基形式交叉共軛二烯醇陰離子可作為新穎之二烯，與親二烯物進行陰離子Diels-Alder 環加成反應，得到符合endo形式Diels-Alder環加成之產物。這一新穎二烯所建構位向專一之Diels-Alder產物具有稠化雙環烯酮次結構，在合成化學中可提供各種衍生化發展。
This thesis details the discovery of an unexpected access to endo-form cycloaddition products during our efforts on development of the anionic annulation. The key process is an anionic Diels-Alder cycloaddition between an aldehyde type cross-conjugated dienolate and electron deficient dienophile. This novel reaction enabled the production of fused bicyclic enone substructure in a one-step operation, which allowed us to provide various regio- and stereo-specific derivatives in synthetic organic chemistry.
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