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研究生: 林瑩兒
Lin, Ying-Er
論文名稱: ERAD相關基因derlin-1之功能分析
Functional analysis of ERAD gene derlin-1
指導教授: 桑自剛
Sang, Tzu-Kang
口試委員:
學位類別: 碩士
Master
系所名稱: 生命科學暨醫學院 - 生物科技研究所
Biotechnology
論文出版年: 2009
畢業學年度: 97
語文別: 英文
論文頁數: 45
中文關鍵詞: 功能分析
相關次數: 點閱:2下載:0
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  • Table of Contents Abstract ii 中文摘要 iii Acknowledgement iv Introduction 1 Materials and Methods 5 Results 9 Loss of derlin-1 in Drosophila eye results in the defect of rhabdomeral polarity 9 Overexpressing derlin-1 affects eye development in early onset model 10 Overexpressing derlin-1 could cause eye degeneration in late onset model 11 Overexpressing derlin-1 induced defect may due to impaired ERAD 12 VCP/TER94 specifically rescue the defect of ERAD caused by overexpression of derlin-1 13 N-or C-terminal derlin-1 may play a critical role in derlin-1 mediated toxicity and its function. 15 Discussion 17 Figures 20 Reference 42

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