本論文乃利用國際上評估硼中子捕獲治療(boron neutron capture therapy,簡稱BNCT) 之混合輻射場劑量的實驗方法，應用於清華大學開放式水池反應器(Tsing Hua open-pool reactor,簡稱THOR)。在過去幾年，許多國家如美國、芬蘭、瑞典、日本等等，已將核反應器用於BNCT研究，甚至展開臨床治療。清大亦希望利用THOR朝BNCT研究發展邁進，以造福更多國內的癌症病患。在這之前，應先評估超熱中子束(epithermal neutron beam)之射束特性，以及假體劑量分佈。
BNCT治療環境為一混合輻射場：由反應器產生的超熱中子束，其中子的能量為一個範圍的分布，且會有伴隨著光子產生；此外，當中子束進入病人體內，除了與含硼藥物發生作用，亦會和人體正常組織反應。為瞭解對病人之影響，必須經由一些特殊量測方法分別評估各種輻射的劑量貢獻。本論文使用雙游離腔技術(dual ionization chamber technique) 度量得到混合輻射場中光子和快中子劑量；採用鎘差法 (cadmium difference technique) 得到熱中子通量率，再以不同之中子克馬因數(neutron kerma factor)評估熱中子對於正常組織與腫瘤造成之劑量。實驗結果可得到水假體內不同深度的各種物理劑量，包含以快中子、光子及熱中子劑量為背景，再加上含硼藥物在正常組織與腫瘤中不同硼-10濃度而得到不同的劑量。除物理劑量外，亦針對不同輻射與細胞種類的生物效應求出其相對生物效應加權劑量(relative biological effectiveness weighted dose)。根據深度-生物劑量曲線可評估中子射束在假體中的治療效益，並以治療效益觀察指標和美國麻省理工學院MITR的射束做比較。最後亦針對實驗情況以蒙地卡羅方法模擬各種劑量貢獻，再與實驗結果比較後找出兩者之差異因子，可作為將來BNCT治療計畫的參考依據。

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